THE PHARMACOLOGICAL STUDYING OF THE INFLUENCE OF BUPLEURUM AUREUM L. ON CARDIOVASCULAR AND NERVOUS SYSTEMS

The object of a research is dry extract of thoroughwax golden (Bupleurum aureum L.) grass. The extract contains flavonoids, saponins, polysaccharides, tanning substances of catechine group. The content of phenolic substances as rutin not less than 6%. The dry extract of thoroughwax golden grass possesses the different types of pharmacological activity taped in experiences by in vitro and in vivo (antiinflammatory, antimicrobic, gastroprotektive, hepatoprotective, etc.) also it is surveyed as perspective for the purpose of creation on its basis of a medicinal preparation for treatment of patients with diseases of the digestive system and a liver. At patients with this pathology often as the main and accompanying diagnoses record vegeto-vascular dystonia, neurotic disorders, a hypertension, coronary heart disease, a heart failure and other implications of cardiovascular and psychoneurological disorders therefore preclinical pharmacological studying of influence of extract of a grass of a thoroughwax golden on indicators of cardiovascular and nervous systems is very relevant. The experiments are executed on 40 white nonlinear mice and 30 nonlinear rats. The studying of neurotropic activity of extract of a thoroughwax was carried out with the use of tests: «a hot plate», «edge pressure upon a paw», «the rotating horizontal core», «spontaneous physical activity», «open field». At rats measured the heart rate, systolic and diastolic arterial blood pressure by a noninvasive method with the use of the fotopletizmografic sensor and the Systole and Flogiston hardware and software. By the results of the made experiments it has been established that the extract received from a grass of a Bupleurum aureum, possessing a wide range of pharmacological activity, renders, including, reliable sedative, the anesthetic calming and moderately expressed hypotensive action therefore is perspective for further profound pharmacological studying for the purpose of creation of new effective herbal drugs.