THE LEVEL OF CYTOKINES IN THE SALIVA OF PATIENTS WITH LUNG CANCER OF DIFFERENT HISTOLOGICAL TYPES

DOI: https://doi.org/10.29296/25877313-2018-02-05
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Issue: 
2
Year: 
2018

L.V. Bel'skaya Ph.D. (Chem.), Associate Professor, Omsk State Technical University; JSC «ChemService» (Moscow) E-mail: ludab2005@mail.ru V.K. Kosenok Dr.Sc. (Med.), JSC «ChemService» (Moscow); Omsk State Medical University Zh. Massard Professor, University Hospital of Strasbourg; Chief Oncologist of the University of Strasbourg E.E. Orlova Doctor of Clinical Laboratory Diagnostics, Head of the Immunological Laboratory, Clinical Oncology Dispensary (Omsk)

The optimization of methods of diagnosis and prediction of lung cancer, which occupies a leading position in the structure of oncologi-cal diseases, remains a relevant task up to date. Study objective: to study the level of cytokines and acute-phase proteins in saliva of patients with lung cancer. A case-control study was attended by 121 volunteers, who were divided into 3 groups: primary (diagnosed with lung cancer, n = 70), comparison (with non-malignant lung pathologies, n = 12) and control group (relatively healthy, n = 39). All participants answered the questionnaire, undergone biochemical study of saliva and histological verification of the diagnosis. Cross-group differences were evaluated using the non-parametric criterion. It has been shown that cytokine levels in the saliva of lung can-cer patients and healthy individuals do not differ statistically. The content of IL-2 and IL-4 in saliva reduces in case of both lung cancer and inflammatory lung diseases, whereas the levels of IL-18, IL-8 and TNF-α decrease in lung cancer and grow in non-tumorous pa-thologies. The progression of the tumor causes an increase in the level of proinflammatory cytokines (IL-6, IL-8, IL-18, TNF-α), whereas the levels of IL-2, IL-4 and IL-10 decrease. An increase in the level of C-reactive protein and tumor markers in the dynamics of lung cancer has been noted, but no significant differences from inflammatory lung diseases have been revealed. With different his-tological types of lung cancer, the nature of the changes in the parameters under study is ambiguous: differentiated between neuro-endocrine and non-small cell lung cancer, IL-2 and C-reactive protein, whereas IL-10 and CEA levels can distinguish squamous cell carcinoma from other histological types.

Keywords: 
cytokines
C-reactive protein
saliva
lung cancer

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