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THE APPLICATION OF THE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY FOR SPECIATION ANALYSIS OF ARSENIC AND MERCURY COMPOUNDS IN HUMAN HAIR

DOI: https://doi.org/10.29296/25877313-2018-07-06
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Issue: 
7
Year: 
2018

O.P. Ajsuvakova Ph.D. (Chem.), Leading Research Scientist, All-Russian Scientific-Research Institute of Medicinal and Aromatic Plants (Moscow); Peoples’ Friendship University of Russia (Moscow) E-mail: oajsuvakova@gmail.com A.V. Skalny Dr.Sc. (Med.), Professor, Chief Research Scientist, All-Russian Scientific-Research Institute of Medicinal and Aromatic Plants (Moscow); Peoples’ Friendship University of Russia (Moscow); P.G. Demidov Yaroslavl State University

The inductively coupled plasma mass spectrometry (ICP/MS) is an effective method to determine the ultratrace quantities of a wide range of chemical elements in a variety of samples. The greatest numbers of works in the speciation analysis fieldare related to compounds of arsenic, mercury and selenium. Speciation analysis with the help of ICP/MS allows to conduct the process of establishing by chemical elements (lead, mercury, arsenic, cadmium, etc.) in the patient's hair with differentiating the compounds of the same el-ement according to the level of the influence on the organism, in particular, on the level of toxicity. In the same way qualitative and quantitative determination of inorganic and organic forms of arsenic and mercury (arsenates, arsenates, monomethyl arsenic acid, di-methyl arsenic acid, methylmercury, ethylmercury, mercury(II) salts) can be carried out. Although nails and hair represent a dead formation from the point of view of metabolism, they can be used as a tool for assessing the impact of the environment and profes-sional related factors to the human, in terms of intoxication by compounds of some elements (lead, mercury, arsenic, cadmium, etc.). At the present stage, the main problem in the performing speciation analysis of hair and nails is the issue of probe preparation. Usual-ly, this problem is solved by the extraction from the ground biomaterial of the compounds of the element under the investigation with water at elevated temperature and pressure, followed by the separation on chromatographic columns.
Keywords: 
arsenic
nails
hair
speciation-analysis
extraction
HPLC
ICP/MS

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