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GENDER EFFECTS ON TRACE ELEMENT STATUS IN CHILDREN WITH DOWN’S SYNDROME

DOI: https://doi.org/10.29296/25877313-2018-07-08
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Issue: 
7
Year: 
2018

A.R. Grabeklis Ph.D. (Biol.), Yaroslavl State University; Senior Lecturer, Peoples’ Friendship University of Russia (Moscow) E-mail: andrewgrabeklis@gmail.com I.V. Zhegalova Student, I.M. Sechenov First Moscow State Medical University; Laboratory Assistant, Peoples’ Friendship University of Russia (Moscow) A.A. Skalnaya Student, M.V. Lomonosov Moscow State University A.L. Mazaletskaya Ph.D. (Psych.), Yaroslavl State University S.A. Simakova Student, Yaroslavl State University M.G. Skalnaya Dr. Sc. (Med.), Professor, Peoples’ Friendship University of Russia (Moscow)

The objective of the present study was to assess gender effects on the levels of essential and toxic chemical elements in hair of children with Down’s syndrome. It has been revealed that hair phosphorus in boys and girls with Down’s syndrome exceeded the con-trol values by 36% (p < 0,001) and 30% (p < 0,001), respectively. Boys were also characterized by increased hair magnesium con-tent. At the same time, hair zinc in boys and girls suffering from Down’s syndrome was 54% (p = 0,021) and 109% (p = 0,085) high-er as compared to the control levels. Girls with the syndrome were characterized by higher hair chromium and silicon levels. In con-trast to other metals, in boys and girls with Down’s syndrome hair mercury levels were decreased by a factor of more than 2 (p = 0,088) and 3 (p = 0,031), whereas hair content of lead and arsenic was elevated in boys and girls, respectively. Two-way ANOVA demonstrated a significant factorial interaction (gender*syndrome) only in the case of Cr (p = 0,030) and Hg (p = 0,031). Therefore, the results of the study indicate a possible pathogenic role of trace element imbalance in Down’s syndrome.
Keywords: 
Down’s syndrome
children
phosphorus
metals
hair

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