THE COMPARATIVE PHYTOCHEMICAL AND MICROBIOLOGICAL STUDY OF LIQUID EXTRACTS BASED ON THE FRUITS OF THE CRATAEGUS SANGUINEA PALL. AND CRATAEGUS SUBMOLLIS SARG

DOI: https://doi.org/10.29296/25877313-2019-04-01
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Issue: 
4
Year: 
2019

V.A. Kurkin Dr.Sc. (Pharm.), Head of the Pharmacognosy Department, Samara State Medical University E-mail: Kurkinvladimir@yandex.ru T.V. Morozova Post-graduate Student, Pharmacognosy Department, Samara State Medical University I.K. Shaikhutdinov Post-graduate Student, Pharmacognosy Department, Samara State Medical University A.V. Lyamin Ph.D. (Med.), Associate Professor, Department of General and Clinical Microbiology, Immunology and Allergology, Samara State Medical University O.E. Pravdivtseva Dr.Sc. (Pharm.), Associate Professor, Pharmacognosy Department, Samara State Medical University S.V. Pervushkin Dr.Sc. (Pharm.), Head of the Department of Pharmaceutical Technology, Samara State Medical University A.A. Kretova Student, Pharmaceutical Faculty, Samara State Medical University

The preparations based on hawthorn fruits have cardiotonic action. One of the reasons of chronic cardiovascular pathology are various inflammatory processes in the human body. In this regard it is actual the study the antimicrobial activity of preparations based on the raw materials of various species of the Hawthorn genus (Crataegus L.) among which hawthorn blood-red and Quebec hawthorn are promising. Hawthorn blood-red (Crataegus sanguinea Pall.) is a wild-growing plant which is wide-spread in the territory of our country. Quebec hawthorn (Crataegus submollis Sarg.) is widely cultivated on the territory of the Russian Federation and it is characterized by rapid growth and high yield. Liquid extracts were obtained based on the fruits of two species of hawthorn in a ratio of 1:1 using 70% ethyl alcohol. The determination of the minimal inhibiting concentration was carried out by double serial dilution in broth. As test cultures, we used the following microorganisms: Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Bacillus cereus, Candida albicans. The study of antimicrobial activity against several microorganisms made it possible to reveal the moderate antimicrobial activity of liquid extracts based on the fruits of hawthorn blood-red and Quebec hawthorn. In addition to the above the antifungal activity of the extract based on hawthorn blood-red fruits is more expressed.

Keywords: 
hawthorn blood-red
Crataegus sanguinea Pall.
Quebec hawthorn
Crataegus submollis Sarg.
fruits
flavonoids
antimicrobial activity

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