STUDY OF ACUTE TOXICITY OF DRY EXTRACT OF POTENTILLA ALBA L

DOI: https://doi.org/10.29296/25877313-2019-07-08
Issue: 
7
Year: 
2019

V.V. Bortnikova Ph.D. (Biol.), Leading Research Scientist, Department of Toxicology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) Е-mail: bortnikova.v@уandex.ru A.N. Babenko Ph.D. (Biol.), Leading Research Scientist, Department of Toxicology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) E-mail: alexandra.mogileva@gmail.com O.S. Kuzina Senior Research Scientist, Toxicology Department, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) Е-mail:oskt@list.ru A.I. Radimich Senior Researcher, Department of Phytochemistry and standardization, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) E-mail: vilarnii.meshkov@mail.ru

Purpose. Determine the toxicity parameters of the dry extract of Potentilla alba L. when administered once to laboratory animals. Methods. The acute toxicity of the dry extract of Potentilla alba L. has been studied in BALB/c mice and Wistar rats of both sexes by intraperi-toneal and intragastric administration. Toxicity parameters had determined by the method of Litchfield and Wilcoxon. Results. With a single intraperitoneal injection of the dry extract of Potentilla alba L. mice and rats (males and females), the same type of acute intoxication had observed: motor agitation, grooming, shortness of breath, cyanosis of the auricles and tail. The first death of animals had regis-tered for 2-3 days after administration of the extract and continued for the next two days. The following indicators of average lethal doses for intraperi-toneal administration to mice had established: 160 ± 26 mg/kg (males) and 150 ± 30 mg/kg (females), rats - 260 ± 45 mg/kg (males) and 250 ± 68 mg/kg (females). With a single injection of the dry extract of Potentilla alba L. in the stomach, the LD50 indice for mice and rats increase 40–50 times as compared with intraperitoneal administration and amount to 10,700–12,000 mg/kg for rats and 7,600–8,300 mg/kg for mice. Conclusion. With a single intraperitoneal and intragastric administration to laboratory animals (mice, rats of both sexes) of the dry extract of Potentilla alba L. is of low toxicity

Keywords: 
Potentilla alba L.
dry extract
mice
rats
acute toxicity

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