FIELD RESTHARROW (ONONIS ARVENSIS L.) – PROMISING SOURCE OF SUBSTANCES WITH DIFFERENT BIOLOGICAL ACTIVITY

DOI: https://doi.org/10.29296/25877313-2020-11-01
Issue: 
11
Year: 
2020

V.G. Luzhanin Ph.D. (Biol.), Associate Professor, Saint Petersburg State Chemical Pharmaceutical University (Saint Petersburg) E-mail: vladimir.luzhanin@pharminnotech.com A.O. Ponkratova Post-graduate Student, Saint Petersburg State Chemical Pharmaceutical University (Saint Petersburg) E-mail: anastasiya.ponkratova@yandex.ru A.K. Whaley Post-graduate Student, Saint Petersburg State Chemical Pharmaceutical University (Saint Petersburg) E.A. Grishukova Student, Pharmaceutical Faculty, Saint Petersburg State Chemical Pharmaceutical University (Saint Petersburg) E-mail: ekaterina.grishukova@pharminnotech.com G.P. Yakovlev Dr.Sc. (Biol.), Professor, Saint Petersburg State Chemical Pharmaceutical University (Saint Petersburg)

Field restharrow (Ononis arvensis L.) is a perennial herb from the legume family, represented in Russia by two subspecies: O. arvensis subsp. arvensis and O. arvensis subsp. spinescens. The geographic area in which the plant can be found covers most of the European territory of Russia, Ukraine, Bela-rus, Moldova, the Caucasus and Transcaucasia, as well as the Baltic States, where it reaches the shores of the Gulf of Finland. This review includes the plants botanical description, secondary metabolite composition, as well as the description of the biological and pharmacological activity of O. arvensis. Polyphenolic compounds can be distinguished as the main secondary metabolites of O. arvensis, among which the representative groups are isofla-vones (formononetin, pseudobaptigenin, calicoside, their glycosides and derivatives), dihydroisoflavonoids (sativanone and onogenin, their glycosides and derivatives), pterocarpans (medicarpine and maakiain, their glycosides and derivatives), phenol carboxylic acid (caffeic, chlorogenic, ferulic, etc.). Among other polyphenolic compounds, flavonols, flavones, flavan-3-ols, dihydrochalcones, hydrolyzable tannins, stilbenoids and flavanones have also been found in field restharrow. In folk medicine, Ononis arvensis has found application in the treatment of hemorrhoids, articular rheumatism, diseases of the liver, bladder and kidneys, skin diseases (dermatoses, eczema), as well as a diaphoretic, hemostatic and diuretic agent. There is reliable data on the choleretic, analgesic and antihypoxic effects of O. arvensis aqueous-alcoholic extracts, as well as their effect on the motor function of the gas-trointestinal tract. Extracts from the perennial part of fieldrestharrow showed antibacterial activity against Escherichia coli, Candida albicans, Staphylococ-cus aureus, Pseudomonas aeruginosa and Salmonella typhimurium. Thus, a wide variety of biologically active substances, causing a multidirectional pharmacological effect in this plant, makes O. arvensis a promising plant from which individual compounds can be isolated - that in the future could become potential pharmaceutical substances.

Keywords: 
fieldrestharrow
isoflavonoids
polyphenols
secondary metabolites
biological activity

References: 
  1. Luzhanin V.G., Gel'tman D.V., Rodionov A.V., Jakovlev G.P. Rod Ononis (Fabaceae) vo flore Rossii i sopredel'nyh gosudarstv. Botanicheskij zhurnal. 2013. 98(11):1403–1415.
  2. Chikov P.S. Stal'nik polevoj (stal'nik pashennyj) – Ononis arvensis L, (Ononis hircina JACQ, Ononis Intermedia C.A). Semejstvo bobovye – Leguminosae (Faba¬ceae): Atlas arealov i resursov lekarstvennyh rastenij SSSR. M.: Kartografija. 1983. 340 s.
  3. Luzhanin V.G. Rodionov A.V., Yakovlev G.P. Molecular-phylogenetic study of the genus Ononis (Fabaceae) in the flora of Russia and adjacent. Botanicheskiy zhurnal. 2013; 98(5):629-637.
  4. Denes T., Papp N., Marton K., Kaszas A. et al. Polyphenol content of Ononis arvensis L. and Rhinanthus serotinus oborny used in the Transylvanian ethnomedicine. International journal of pharmacognosy and phytochemistry. 2015; 30(1): 1301–1307.
  5. Denes T., Bartha S.G., Kerenyi M. et al. Histological and antimicrobial study of Ononis arvensis L. Acta Biologica Hungarica. 2017; 68(3):321–333.
  6. Luzhanin V.G., Jakovleva O.V. Stroenie semennoj kozhury i list'ev predstavitelej roda Ononis (Fabaceae) flory Rossii i sopredel'nyh gosudarstv. Botanicheskij zhurnal. 2014; 99(6):662–670.
  7. Wdowiak-Wrobel S., Marek-Kozaczuk M., Kalita M. et al. Diversity and plant growth promoting properties of rhizobia isolated from root nodules of Ononis arvensis. Antonie van Leeuwenhoek. 2017; 110(8):1087–1103. DOI:10.1007/s10482-017-0883-x
  8. Kovalev V.N., Spiridonov V.N., Borisov M. et al. Phenolic compounds of Ononis arvensis. Chemistry of natural com¬pounds. 1974; 10: 820–821.
  9. DOI: 10.1007/bf00564018.
  10. Gampe N., Darcsi A., Nedves A.N., Boldizsar I. et al. Phytochemical analysis of Ononis arvensis L. by liquid chromatography coupled with mass spectrometry. Journal of Mass Spectrometry. 2018; 54 (2):1–30. DOI:10.1002/jms.4308
  11. Rowan M.G., Dean D.G. -onocerin and sterol content of twelve species of ononis. Phytochemistry. 1972; 11:3263-3265. DOI:10.1016/S0031-9422(00)86384-0.
  12. Tumova L., Skrbkova E., Dusek J. Effect of ultrasound on the production of flavonoids by the culture of Ononis arvensis L. in vitro. Ceska a Slovenska farmacie. 2006; 55(1):40–43.
  13. Tumova L. The effect of elicitors from Pseudomonas aeruginosa on the production of flavonoids in cultures of Ononis arvensis L. Ceska a Slovenska farmacie. 1999; 48(6):262–264.
  14. Tumova L., Tuma J., Dolezal M. Ryrazinecarboxamides as potential elicitors of flavonolignan and flavonoid production in Silybum marianum and Ononis arvensis cultures in vitro. Molecules. 2011; 16:9142–9152. DOI: 10.3390/molecules16119142
  15. Tulajkin A.I., Bahtina S.M. Diureticheskaja i anal'gezirujushhaja aktivnost' izvlechenij iz nadzemnoj chasti Ononis arvensis (Fabaceae). Rastitel'nye resursy. 2006; 42(1):120–126.
  16. Tulajkin A.I., Jakovlev G.P. Izuchenie himicheskogo sostava travy stal'nika polevogo. Farmacija. 2007; 2:10–11. Kovalev V.N., Spiridonov V.N., Borisov M. et al. Phenolic compounds of Ononis arvensis the structure of onogenin. Chemistry of natural compounds. 2004; 11(3):367–369.
  17. Kovalev V.N., Borisov M., Spiridonov V.N., et al. Phenolic compounds of Ononis arvensis III. Chemistry of natural compounds. 1976; 12(1): 95–96.
  18. Tulajkin A.I., Strelkova L.F., Berezina V.S. Uglevody nadzemnoj chasti Ononis arvensis (Fabaseae): struktura polisaharidov. Rastitel'nye resursy. 2005; 41(4):73–80.
  19. Gosudarstvennaja farmakopeja Rossijskoj Federacii MZ RF. XIV izd. T. 3. M. 2018. S. 6443–6450.
  20. Davitavjan N.A., Sampiev A.M. Mineral'nyj sostav travy stal'nika polevogo. Fundamental'nye issledovanija. 2012; 6(2):482–484.
  21. SampievA.M., Davitavjan N.A. Sravnitel'noe izuchenie farmakologicheskoj aktivnosti jekstraktov iz travy i nastojki iz kornej stal'nika polevogo. Kubanskij nauchnyj medicinskij vestnik. 2006; 12:102–105.