ASSESSMENT OF BILE ACTIVITY OF MULTICOMPONENT PLANT EXTRACT "PENTAFIT"

DOI: https://doi.org/10.29296/25877313-2021-04-02
Issue: 
4
Year: 
2021

E.V. Ferubko Ph.D. (Med.), Head of Department of Experimental Pharmacology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia) Е-mail: eferubko@yandex.ru S.M. Nikolaev Dr.Sc. (Med.), Professor, Chief Research Scientist, Laboratory of Experimental Pharmacology, General and Experimental Institute of Biology, Siberian branch of RAS (Ulan-Ude, Russia) Е-mail: smnikolaev@mail.ru T.D. Dargaeva Dr.Sc. (Pharm.), Professor, Chief Research Scientist, Department of Chemistry of Natural Compounds, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia) E-mail: vilarnii@mail.ru

In the structure of morbidity and mortality of the population, liver lesions occupy a leading place due to an increase in the number of uncontrolled large-scale use of drugs, pollution of the environment with chemical compounds, alcoholic intoxications. Promising for the development of pharmacological correction methods for these conditions are multicomponent agents of plant origin, characterized by the breadth of therapeutic action, low toxicity and associated long-term use without the risk of developing side reactions. The advantage of multicomponent drugs is the mutual enhancement of the beneficial pharmacological properties of each incoming ingredient, the correspondence of the multivalence of the pathogenesis of the disease, the ef-fect on the patient's body as a whole. The article presents the results of studying the bile activity of the multicomponent plant extract, under the condi-tional name «Pentafit»obtained from the following types of plant raw materials: of the roots and rhizomes of Inula helenium L. - 250 g, the herb of Cen-taurium ery-thraea Rafn. - 150 g, theflowers of Tanacetum vulgare L. - 100 g, thefruits of Rosa sp. - 275 g, the fruits of Crataegus sp. 225 g under car-bon tetrachloride hepatitis model conditions. It was found that course administration per os «Pentafit» at a dose of 300 mg/kg to white nonlinear rats with carbon tetrachloride liver damage increases simultaneously the bile and bile function of the liver in animals. The bile effect of the extract in toxic liver damage is due to the presence in it of a complex of biologically active substances and, above all, phenolic compounds. The obtained research re-sults argue the feasibility of using a multicomponent plant extract «Pentafit» containing biologically active substances of phenolic nature, in the com-plex treatment and prevention of liver diseases.

Keywords: 
multicomponent plant extract «Pentafit»
choleretic activity
model of toxic hepatit

References: 
  1. Ivashkin V.T. Gastrojenterologija: nacional'noe rukovodstvo. M.: GJeOTAR-Media, 2008; 704 s.
  2. Nikolaev S.M. Fitofarmakoterapija i fitofarmakoprofilaktika zabolevanij. Ulan-Ude: Izd-vo BGU, 2012; 286 s.
  3. Sokolov S.Ja. Fitoterapija i fitofarmakologija. Rukovodstvo dlja vrachej. M.: MIA, 2000; 976 s.
  4. Lubsandorzhieva P.-N.B. Razrabotka i standartizacija fitosredstv dlja lechenija i profilaktiki zabolevanij organov pishhevarenija. Ulan-Udje: Izd-vo BNC SO RAN, 2016; 280 s.
  5. Patent № 2689379 Rossijskoj Federacii. Sposob poluchenija sredstva, obladajushhego antigepatotoksicheskoj aktivnost'ju / Ferubko E.V., Nikolaev S.M., Dargaeva T.D. № 2019106135/19; zajavl. 05.03.2019; opubl. 28.05.2019. Bjul. № 16.
  6. Rukovodstvo po provedeniju doklinicheskih issledovanij lekarstvennyh sredstv. Chast' pervaja. M.: Grif i K, 2012; 944 s.
  7. Borovikov V.P. Populjarnoe vvedenie v sovremennyj analiz dannyh v sisteme STATISTICA. M.: Gorjachaja linija. Telekom, 2014; 288 s.
  8. Bueverov A.O. Lekarstvennye porazhenija pecheni. Rossijskij medicinskij zhurnal. 2012; 3: 107-110.
  9. Korsun V.F., Nikolaev S.M., Ogrenich M.A., Korsun E.V., Bartanova E.A., Sultanbekov B.A. Lekarstvennye rastenija i bolezni pecheni. M.: Izdatel'stvo Mjejler, 2014; 320 s.