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REVIEW OF METHODS FOR PHARMACEUTICAL ANALYSIS OF SULFUR-CONTAINING ANTIOXIDANTS

DOI: https://doi.org/10.29296/25877313-2021-05-02
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Issue: 
5
Year: 
2021

T.G. Shinko Post-graduate Student, Pharmaceutical Department, Novosibirsk State Medical University (Novosibirsk, Russia) E-mail: shinko.tatiana@yandex.ru S.V. Terentyeva Dr.Sc. (Pharm.), Novosibirsk State Medical University (Novosibirsk, Russia) E-mail: terentyeva_sv@mail.ru E.A. Ivanovskaya Dr.Sc. (Pharm.), Professor, Novosibirsk State Medical University (Novosibirsk, Russia) E-mail: el-ivanovskaja@yandex.ru

Antioxidant protection is an effective and recognized way to control the free-radical oxidative mechanism in live organisms. Antioxidants are widely used in the treatment of hepatitis, atherosclerosis, and malignancies. One of the promising directions for the synthesis of new antioxidants is the in-clusion of sulfur in its structures. Sulfur is an element that is easily oxidized and, in addition, is able to bind heavy metal cations. Methods for pharma-ceutical analysis of such pharmaceuticals should estimate adequate the condition of important functional groups and, if it is possible, correlate with antioxidant effect. In this research work methods for quality control of sulfur-containing antioxidant in pharmaceuticals and biosamples are reviewed. For this reason methods for analysis of thioctic acid, probucol, bucillamine and disulfiram, represented in European Pharmacopoeia 8th edition, USP 41, British Pharmacopoeia 2016, Japanese Pharmacopoeia 17th edition, were analysed. It was estimated, that along with reliable pharmacopoeial quantifi-cation methods, such as titrimetry, spectrophotometry, and high-performance liquid chromatography, electrochemical methods are being actively de-veloped for the analysis of antioxidants. These methods can be used definitely or as detection for chromatography. Quantitative determination based on the redox potential of antioxidants can adequately reflect the functional state of such pharmaceuticals and thus guarantee its efficacy. Due to their high sensitivity and relative ease of sample preparation, electrochemical methods can also be used to determine the content of sulfur-containing anti-oxidants in biological samples. However, most of the considered methods of analyzing drugs in biosamples are chromatographic. This is because HPLC allow to determine at once pharmaceuticals and its metabolites, and HPLC-MS enable to identify the structure of metabolites.
Keywords: 
sulfur-containing antioxidants
quality control
pharmaceutical analysis

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References: 
  1. Tregubova I.A., Kosolapov V.A., Spasov A.A. Antioksidanty: sovremennoe sostojanie i perspektivy. Uspehi fiziologicheskih nauk. 2012; 43(1):75–94.
  2. Navari-Izzo F., Quartacci M.F., Sgherri C. Lipoic acid: A unique antioxidant in the detoxification of activated oxygen species. В: Plant Physiology and Biochemistry. 2002; 40(6-8): 463–470.
  3. Wielandt A.M., Vollrath V., Farias M., Chianale J. Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2. Biochem Pharmacol. 2006; 72(4): 455–462.
  4. Zimetbaum P., Eder H., Frishman W. Probucol: Pharmacology and clinical application. Journal of Clinical Pharma¬cology. 1990; 30: 3–9.
  5. Zolotareva M.S., Tjukova V.S. Validacija metodiki kolichestvennogo opredelenija disul'firama v substancii na osnove kompleksa vkljuchenija gidroksipropil-β-ciklodekstrina s disul'firamom. Sovremennaja nauka: issledovanija, tehnologii, proekty. Sbornik V mezhdunar. nauch.-praktich. konf. (Moskva, 8 nojabrja 2015 g.). 2015; 251-258.
  6. Kaul L., Süss R., Zannettino A., Richter K. The revival of dithiocarbamates – from pesticides to innovative medical treatment. iScience. 2021; 24(2): 102092.
  7. Patent № 2426097 Rossijskaja Federacija, MPK G01N 21/78. Sposob kolichestvennogo opredelenija lekarstvennyh veshhestv v farmakopejnyh preparatah. V.P. Kalashnikov, A.I. Slivkin, L.Ju. Jakovlev; zajavitel' i patentoobladatel' GOU VPO «Voronezhskij gosudarstvennyj universitet». №2010106669/28; zajavl. 24.02.2010; opubl. 10.08.2011; bjul. № 22. 9 s.
  8. Bunaciu A.A., Aboul-Enein H.Y., Fleschin Ş. Quantitative analysis of bucillamine and its pharmaceutical formulation using FT-IR spectroscopy. Farmaco. 2005; 60(8): 685–688.
  9. Walash M.I., Metwally M.E.S., El-Brashy A.M., Abdelal A.A. Kinetic spectrophotometric determination of some sulfur containing compounds in pharmaceutical prepara-tions and human serum. Farmaco. 2003; 58(12): 1325–1332.
  10. Siangproh W., Rattanarat P., Chailapakul O. Reverse-phase liquid chromatographic determination of α-lipoic acid in dietary supplements using a boron-doped dia-mond electrode. J. Chromatogr. A. 2010; 1217(49): 7699-7705.
  11. Charoenkitamorn K., Chailapakul O., Siangproh W. Development of gold nanoparticles modified screen-printed carbon electrode for the analysis of thiram, disulfiram and their derivative in food using ultra-high performance liquid chromatography. Talanta. 2015; 132: 416-423.
  12. Nourooz-Zadeh J., Gopaul N.K., Forster L.A., Ferns G.A., Änggård E.E. Measurement of plasma probucol levels by high-performance liquid chromatography. J. Chromatogr. B: Biomed. Sci. Appl. 1994; 654(1): 55–60.
  13. Lee K.C., Chun Y.G., Kim I., Shin B.S., Park E.S., Yoo S.D. Development and validation of a reversed-phase fluorescence HPLC method for determination of bucilla-mine in human plasma using pre-column derivatization with monobromobimane. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2009; 877(22): 2130–2134.
  14. Haj-Yehia A.I., Assaf P., Nassar T., Katzhendler J. Determination of lipoic acid and dihydrolipoic acid in human plasma and urine by high-performance liquid chroma-tography with fluorimetric detection. J. Chromatogr. A. 2000; 870(1–2): 381–388.
  15. Khan A., Khan M.I., Iqbal Z., Ahmad L., Shah Y., Watson D.G. Determination of lipoic acid in human plasma by HPLC-ECD using liquid-liquid and solid-phase extrac-tion: Method development, validation and optimization of experimental parameters. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2010; 878(28): 2782–2788.
  16. Zhang L., Jiang Y., Jing G., Tang Y., Chen X., Yang D. A novel UPLC-ESI-MS/MS method for the quantitation of disulfiram, its role in stabilized plasma and its applica-tion. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2013; 937: 54–59.
  17. Chen J., Jiang W., Cai J., Tao W., Gao X., Jiang X. Quantification of lipoic acid in plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2005; 824(1–2):249–257.
  18. Charoenkitamorn K., Chaiyo S., Chailapakul O., Siangproh W. Low-cost and disposable sensors for the simultaneous deter¬mination of coenzyme Q10 and α-lipoic ac-id using man¬ganese (IV) oxide-modified screen-printed graphene electrodes. Anal. Chim. Acta. 2018; 1004: 22–31.
  19. Smarzewska S., Festinger N., Skowron M., Guziejewski D., Metelka R., Brycht M. Voltammetric analysis of disulfiram in pharmaceuticals with a cyclic renewable silver amalgam film electrode. Turkish J. Chem. 2017; 41(1): 116–124.
  20. Marin M., Lete C., Manolescu B.N., Lupu S. Electrochemical determination of α-lipoic acid in human serum at platinum electrode. J. Electroanal. Chem. 2014; 729: 128–34.