DOI: https://doi.org/10.29296/25877313-2021-12-08

A.V. Skalny Dr.Sc. (Med.), Professor, Sechenov University; RUDN University (Moscow, Russia) J.-S. Chang PhD, Taipei Medical University (Taipei, Taiwan) V.N. Nikolenko Dr.Sc. (Med.), Professor, Sechenov University (Moscow, Russia) S.-Y. Huang PhD, Taipei Medical University (Taipei, Taiwan) D.A. Zotkin Assistant, Sechenov University (Moscow, Russia) W. Wang PhD, Taipei Medical University (Taipei, Taiwan) A.A. Tinkov Ph.D. (Med.), Sechenov University; Associate Professor, RUDN University (Moscow, Russia) E-mail: tinkov.a.a@gmail.com

The objective of the study was to evaluate essential metal levels in subcutaneous and visceral adipose tissue samples from patients with morbid obesity. Adipose tissue samples were collected from 10 women with morbid obesity (BMI > 35) aged 30-50 y.o. Assessment of iron (Fe), copper (Cu), manganese (Mn), zinc (Zn), and selenium (Se) levels in adipose tissue samples was performed using inductively coupled plasma mass spectrometry. The obtained data demonstrate that iron and copper levels in visceral adipose tissue were 68% (р = 0,021) and 38% (р = 0,053) higher as compared to subcutaneous depot. No difference in tissue Mn, Se, and Zn levels were observed. The obtained values generally correspond to those reported in studies from Spain, Italy, and Lithuania. Correlation analysis demonstrated positive association between subcutaneous adipose tissue Fe, visceral adi-pose tissue Fe and Cu contents, and BMI values. Therefore, the obtained findings demonstrate heterogeneity of adipose tissue metal levels in patients with morbid obesity with predominant accumulation of Fe and Cu in visceral adipose tissue.

mass spectrometry

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