INSECTICIDAL ACTIVITY OF DERIVATIVES OF THE BUTENDIOVICAL ACIDS

Issue: 
8
Year: 
2015

B.Ya. Syropâtov
Dr.Sc. (Med), Professor, Department of Physiology of the Basics of Anatomy, Perm State Pharmaceutical Academy
syropyatov@mail.ru
N.V. Kolotova
Ph.D. (Chem.), Assistant Professor, Department of Analytical Chemistry, Perm State Pharmaceutical Academy
E-mail: kolotova-nina@rambler. ru
E.A. Maschkina
Student, Perm State Pharmaceutical Academy
E-mail: elenka_mashkina @mail.ru
I.A. Popova
Student, Perm State Pharmaceutical Academy
E-mail: irinkapopova 94@mail.ru

The insecticidal activity of 27 substituted amides and hydrazides and hydrazides salts of maleic, citraconic and dimethylmeleic acides on mosquito larvae Chironomide has been studied. The mosquito larvae (bloodworms) were placed into 0.1% solution of the test compounds and their time of death was fixed. The models were imidacloprid, diazinon and pirimiphos. The acute toxicity (LD50) of the most active compound (n-metoksibenzoilgidrazida maleic acid) was determined by intravenous injection of an aqueous solution to white mice weighing 16−20 g. The results were processed according to Prozorovsky with the calculations of the average lethal dose (LD50) at P = 0.05. The studies have shown that nine compounds exceed the insecticidal activity of imidacloprid, four compounds are more active in comparison with Diazinon and pirimiphos. n-Metoksibenzoilgidrazid of maleic acid makes the life of mosquito larvae Chironomide 3 times shorter as compared to imidacloprid and more than 2 times as active as diazinon. LD50 of Metoksibenzoilgidrazid of n-maleic acid when administered intravenously is 600 (566−636) mg / kg. LD50 of Imidacloprid when given orally is 112 (64,8−163,9) mg / kg. The regularity dependence of the insecticidal activity and the structure of the compounds was established. In some cases, the maleic component of the compounds gives anti-mosquito activity as compared to the same derivatives of citraconic and dimethylmaleic acids.

Keywords: 
Keywords: amides
hydrazides of the maleic
citraconic
dimethylmaleic acids
antimosquito activity.