THE EFFECT OF THERMOPSIS (THERMOPSIS LANCEOLATA R. BR.) DRY EXTRACT ON THE EMBRYOGENESIS OF RATS

Issue: 
1
Year: 
2016

L.V. Krepkova
Ph.D. (Biol.), Head of Toxicology Department, All-Russian Scientific Research Institute of Medical and Aromatic Plants (VILAR) (Moscow)
E-mail: krepkowa2011@yandex.ru
T.B. Savinova
Ph.D. (Biol.), Leading Research Scientist, Toxicology Department,
All-Russian Scientific Research Institute of Medical and Aromatic Plants (VILAR) (Moscow)
E-mail: tamarasavinova@yandex.ru
V.V. Bortnikova
Ph.D. (Biol.), Leading Research Scientist, Toxicology Department,
All-Russian Scientific Research Institute of Medical and Aromatic Plants (VILAR) (Moscow)
E-mail: bortnikova.v@yandex.ru
M.V. Borovkova
Senior Research Scientist, Toxicology Department, All-Russian Scientific Research Institute of Medical and Aromatic Plants (VILAR) (Moscow)
E-mail: borovkova_65@mail.ru
O.P. Dmitrieva
Ph.D. (Biol.), Leading Research Scientist, Toxicology Department,
All-Russian Scientific Research Institute of Medical and Aromatic Plants (VILAR), Moscow
N.I. Sidel`nikov
Dr. Sc. (Agricul.), Director, All-Russian Scientific Research Institute of Medical and Aromatic Plants (VILAR), Moscow

The study оf embryotoxic and teratogenic properties of thermopsis dry extract (Thermopsis lanceolata R. Br.) (Fabaceae). Thermopsis dry extract included into the composition of such a modern multi expectorants of drugs «Codelac broncho» «Codecan», «Antitussin», «Аmtersol», «Codelac phyto», «Cough drops» etc. Long-term administration of studied extracts in to the stomach of rats on 1 -19th dais of pregnancy in doses of 6.0 mg/kg and 18.0 mg/kg (6 - and 16-fold daily therapeutic) had no effect on intrauterine death of embryos, but decreased the body weight and the size of craniocaudal 20-day fetuses, violated the process of ossification of their skeleton. Thermopsis dry extract in tested doses did not affect the body weight and survival of rat pups in the postnatal period of development, causing violation of their vestibular function, motor coordination and emotional-motor behavior. Thus preparations containing thermopsis dry extract is contraindicated in pregnancy.

Keywords: 
Key words: thermopsis dry extract
embryotoxi and teratogenic properties.