APPLICATION OF THE ACID PROMOTED CYCLIZATION OF NITRILES FOR THE SYNTHESIS OF 3-AMINOISOQUINOLINES (REVIEW)

Issue: 
2
Year: 
2016

G.B. Lapa
Ph.D. (Chem.), Senior Research Scientist, N.N. Blokhin Russian Cancer Research Center (Moscow)
E-mail: lapa_g@mail.ru
O.N. Tolkachev
Dr.Sc. (Chem.), Professor, All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)
E-mail: vilarnii@mail.ru

Review on the simple and efficient method of 3-aminoisoquinolines synthesis using acid promoted cyclocondensation of nitriles and production of their functionally substituted derivatives is presented. Their reaction mechanisms and dynamic of the reaction process are discussed. Naturally occurring alkaloids analogues e.g. 3-aminopapaverine are produced and studied. Solid phase determination of papaverine in biolological liquids and in the cell cultures is worked out. Spectral characteristics of 3-aminoisoquinolines, results of their biological activities and the prospects of their use in medicine are also discussed.

Keywords: 
Key words: 3-aminoisoquinolines
synthesis
transformations
reactions mechanisms
biological activities.