EXPERIMENTAL MODELLING IN GASTROENTEROLOGY. PRACTICAL GUIDELINES. PART II. EXPERIMENTAL MODELS OF ACUTE ULCER LESIONS OF THE STOMACH

Issue: 
3
Year: 
2016

A.I. Baginskaya
Ph.D. (Med.), All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)
E.V. Ferubko
Ph.D. (Med.), Head of Department of Experimental and Clinical Pharmacology,
All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)
E-mail: ekaterina-ferubko@rambler.ru
E.N. Kurmanova
Research Scientist, Department of Experimental and Clinical Pharmacology,
All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)
I.V. Voskoboynikova
Ph.D. (Pharm.), Leading Research Scientist, Department of Experimental and Clinical Pharmacology,
All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)
V.K. Kolkhir
Dr.Sc. (Med.), Chief Research Scientist, Department of Experimental and Clinical Pharmacology,
All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)

The article presents summarized domestic (including own) and foreign experience of screening and preclinical studies of potential antiulcer (gastroprotective) biologically active substances (BAS). We suggest the most expedient approaches to search and development of BAS (both natural and synthetic) proposed for treatment of gastrointestinal disorders using models of gastric and duodenal erosive-ulcerative lesions, which reflect main factors of ulcer development. These approaches take into account the main requirements to screening and preclinical studies of therapeutic agents: quick obtaining of results, reliability of results, and minimal expenses.

Keywords: 
Key words: еxperimental models of gastric and duodenal ulcer
ulcerogenic activity
gastroprotective effect.