USAGE OF OZONE IN CO MPLEX TREATMENT OF MILITARY PERSONNEL WITH ATOPIC DERMATITIS

Issue: 
5
Year: 
2016

A.V. Apchel
Ph.D. (Med.), Chief of the Department of the Skin and Venereal Diseases, 3rd Military Hospital Russian Interior Troops (St.-Petersburg)
E-mail: apchelandrey@mail.ru
A.M. Ivanov
Dr.Sc. (Med.), Professor, Head of of Clinical Biochemistry and Laboratory Diagnostics,
S.M. Kirov Military-Medical Academy (St.-Petersburg)
D.V. Zaslavskiy
Dr.Sc. (Med.), Professor, Department of Dermatology, Saint-Petersburg State Pediatric Medical University

We presented data of immunological examination of internal troops with atopic dermatitis and their dynamics depending on the use of ozone therapy. The immune profile meets surveyed Th2-directed immune response. Statistically significant (p < 0,05) differences in immunological parameters in personnel with atopic dermatitis compared with healthy. Defined increase in the expression B-cell marker CD19+ (17,6±1,6%, 0,48±0,04 pg/ml; healthy – 6,3%±2,4, 0,23±0,04 pg/ml, respectively), the level of serum IL-4 (6,2±0,21 pg/ml; healthy – 1,5±1,12 pg/ml, respectively) and a pro-inflammatory cytokine TNF-α (4,8±4,1 pg/ml; healthy – 1,8±3,2 pg/ml, respectively), a relative decrease of CD3+ T-cells (61,1±1,8%; healthy – 71,5±1,9%, respectively) and CD3+CD8+ (20,7±2,6%; healthy – 29,2±2,1%, respectively). After the ozone therapy normalized baseline indicators modified immune cell component CD3+ and CD3+CD8+ (72,5±1,4 and 28,9±2,2%, respectively), decreased levels of cytokines TNF-α and IL-2 (2,6±3,5 and 1,1±0,5 pg/ml, respectively). The immunological data obtained during the study allows characterize chronic skin disease as T-cell-associated atopic dermatitis. We confirmed the immunomodulating effect of ozone therapy.

Keywords: 
Key words: internal troops
ozonotherapy
psoriasis
eczema
atopic dermatitis
chronic dermatoses
immune status
immunotherapy
cellular link of immunity.