EXPERIMENTAL MODELLING IN GASTROENTEROLOGY. PRACTICAL GUIDELINES. PART IV. ЕXPERIMENTAL MODELS OF SUBCHRONIC AND CHRONIC GASTRIC AND DUODENAL ULCER

Issue: 
5
Year: 
2016

A.I. Baginskaya
Ph.D. (Med.), All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)
E.V. Ferubko
Ph.D. (Med.), Head of Department of Experimental and Clinical Pharmacology,
All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)
E-mail: ekaterina-ferubko@rambler.ru
E.N. Kurmanova
Research Scientist, Department of Experimental and Clinical Pharmacology,
All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)
I.V. Voskoboynikova
Ph.D. (Pharm.), Leading Research Scientist, Department of Experimental and Clinical Pharmacology,
All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)
V.K. Kolkhir
Dr.Sc. (Med.), Chief Research Scientist, Department of Experimental and Clinical Pharmacology,
All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow)

In 4 parts of article presents investigation of the drug effect on gastric/duodenal mucosa integrity upon subchronic and chronic treatment with ulcer inducers. Preventive and therapeutic schemes of drug administration are studied for more complete characterization of the drug anti-ulcer activity. Methods of animal sacrifice at the end of experiments are described. Upon autopsy and stomach/duodenum withdrawal, their mucosa must be inspected visually to count the number of lesions/ulcers and to measure their area. The drug therapeutic efficacy will be calculated by Pauls`s index. Methodological recommendations presented here will allow the investigators to choose the most appropriate models for screening and preclinical study of biologically active substances with anti-ulcer activity.

Keywords: 
Key words: еxperimental models of subchronic and chronic gastric and duodenal ulcer
ulcerogenic activity
gastroprotective effect.