WOUND HEALING POTENTIAL OF SOFT DOSAGE FORMS WITH COPPER NANOPARTICLES AND LOW MOLECULAR WEIGHT CHITOSAN DERIVATIVES

Issue: 
7
Year: 
2016

A.A. Rakhmetova
Ph.D. (Biol.), Research Scientist, Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences (Moscow)
E-mail: alla8405@yandex.ru
O.A. Bogoslovskaja
Ph.D. (Biol.), Associate Professor, Leading Research Scientist,
Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences (Moscow)
E-mail: obogo@mail.ru
I.P. Olkhovskaya
Chief Research Scientist, Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences (Moscow)
E-mail: nanobiology@rambler.ru
A.N. Zhigach
Ph.D. (Phys.-Math.), Deputy Director, Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences (Moscow)
E-mail: yyleibe@yandex.ru
A.V. Iljina
Ph.D. (Chem.), Leading Research Scientist, Centre «Bioengineering» of Russian Academy of Sciences (Moscow)
E-mail: varlamov@biengi.ac.ru
V.P. Varlamov
Dr.Sc. (Chem.), Professor, Head of Laboratory, Institute for Energy Problems of Chemical Physics,
Russian Academy of Sciences (Moscow)
E-mail: varlamov@biengi.ac.ru
N.N. Glushchenkо
Dr.Sc. (Biol.), Professor, Head of Laboratory, Institute for Energy Problems of Chemical Physics,
Russian Academy of Sciences (Moscow)
E-mail: nnglu@mail.ru

This article is focused on the wound-healing effects of combined medications with chitosan derivatives and copper nanoparticles comixed into the ointment composition. To create wound repairing farmaceuticals containing copper nanoparticles and low molecular weight chitosan derivatives, a copper nanoparticles synthesis and a consequent surface modification with a variety of physical and chemical factors were made; then nanoparticles’ physicochemical characteristics were determined and the formulation technology of the ointment processed. Modification technologies let us to get copper nanoparticles differing in size, phase structure, oxide film width and formula. Physicochemical characteristics of copper nanoparticles were shown to influence their wound-healing effects. Chitosan derivatives Osulfochitosan and N-sulfosuccinyl-N-carboxymethylchitosan included into ointment composition were synthethised to study wound repairing effectiveness of low molecular weight chitosans. The second one was shown to increase the specific healing rate in comparison with control composition without chitosans. But the maximum repairing effects showed complex preparations with copper nanoparticles of sample № 1 and N-sulfosuccinyl-N−carboxymethylchitosan, and sample № 2 combined with O-sulfochitosan in comparison with ointments containing only individual components. The ointments developed also demonstrated a pronounced antibacterial action. It was stated that ointments had got from both compounds in a definite proportions and concentrations with proper physicochemical characteristics of copper nanoparticles and chitosan derivatives structure could potentiate antibacterial and wound healing effects of each other.

Keywords: 
Key words: copper nanoparticles
chitosan derivatives
wound healing
dosage forms.