ANTIVIRAL ACTIVITY OF AMINO ACID DERIVATIVES OF 1,3-ADAMANTANEACETIC ACID AGAINST THE VIRUS OF AVIAN INFLUENZA A(H5N1)

Issue: 
7
Year: 
2016

V.A. Shibnev
Dr.Sc. (Chem.), Professor, Leading Research Scientist of the Laboratory of Ontogenesis Viruses,
N.F. Gamaleya FRCEM Ministry of Health of Russia
E-mail: shibnev@yandex.ru
P.G. Deryabin
Dr.Sc. (Med.), Professor, Deputy Director for scientific work, D.I. Ivanovsky Institute of Virology, N.F. Gamaleya FRCEM Ministry of
Health of Russia
E-mail: pg_deryabin@mail.ru (Virology)
P.P. Purygin
Dr.Sc. (Chem.), Professor, Head of the Department of Organic, Bioorganic and Medicinal Chemistry,
Samara State Aerospace University
E-mail: puryginpp2002@mail.ru
I.K. Moiseev
Dr.Sc. (Chem.), Professor, Department of Organic Chemistry, Samara State Technical University
E-mail: ikmoiseev@mail.ru
K.M. Bormasheva
Ph.D. (Chem.), Senior Lecturer in Organic Chemistry, Samara State Technical University
E-mail: borks@mail.ru
T.M. Garaev
PhD, Senior Research Scientist of the Laboratory of Ontogenesis Viruses, N.F. Gamaleya FRCEM Ministry of Health of Russia
E-mail: gtim@fmradio.ru
M.P. Finogenova
Ph.D., Leading Research Scientist of the Laboratory of Ontogenesis Viruses, N.F. Gamaleya FRCEM Ministry of Health of Russia
E-mail: fimapa@yndex.ru
A.G. Botikov
Senior Research Scientist of the Laboratory of the State Collection of Viruses,
D.I. Ivanovsky Institute of Virology N.F. Gamaleya FRCEM Ministry of Health of Russia
E-mail: tessey@mail.ru
D.V. Mishin
Research Scientist of the Laboratory of the Institute of State Collection of Viruses,
D.I. Ivanovsky Institute of Virology N.F. Gamaleya FRCEM Ministry of Health of Russia
E-mail: priz-85@mail.ru

Synthesized new amino acid derivatives with 1,3-adamantaneacetic acid and investigated their antiviral activity against influenza virus A/H5N1 in vitro. On the cell culture Vero-E6 shows that the proposed compounds are low in toxicity and have the ability to inhibit replication of influenza virus A/H5N1. Compounds 1,3-Ad-(CH2-Thr-OMe)2, 1,3-Ad-(CH2-Thr-OEt)2 and 1,3-Ad-(CH2-Ser-OMe)2 exhibited high activity in all the experiments performed in vitro. Furthermore, some compounds have been revealed a high virucidal activity against viral particles of influenza A/H5N1.

Keywords: 
Key words: influenza A/H5N1
adamantane derivatives
amino acids
antiviral activity
resistance.