GENE EXPRESSION MARKERS IN CLEAR CELL RENAL CARCINOMA

Issue: 
7
Year: 
2016

T.A. Zhinzhilo
Doctor of Clinical Laboratory Diagnostics, Medical and Rehabilitation Center (Moscow)
A.V. Kolpakov
Surgeon, Head of Department of Urology, V.D. Babenko Tambov Regional Clinic
D.S. Mikhaylenko
Ph.D. (Med.), Leading Researcher, N.A. Lopatkin Research Institute of Urology and Interventional Radiology –
branch of the National Medical Research Radiological Center (Moscow)
T.V. Kekeeva
Ph.D. (Med.), Leading Researcher, Laboratory of Epigenetics, Medical Genetics Research Center (Moscow)
N.E. Kushlinskii
Dr.Sc. (Med.), Professor, Member-Correspondent of Russian Academy of Sciences,
Moscow State University of Medicine and Dentistry after name A.I. Evdokimov

Renal cancer (RC) is a common cancer of the genitourinary system. Clear cell renal cell carcinoma (ccRCC) is the most common histological type of RC. In most cases diagnosis and prognosis of ccRCC based on the data of instrumental tests, while research and characterization of the novel molecular markers of RC remains relevant. Genetic events and subsequent changes in gene expression are the basis of carcinogenesis, although diagnostic panels of the expression markers of RC still not widely accepted. This review represents the recent results of research in the area of gene expression markers of RC. Analysis of expression profiles for developing prognostic test-systems seems an actual problem in modern oncologic urology.

Keywords: 
Key words: renal cancer
clear cell renal carcinoma
gene expression.