ELABORATION METHODS OF QUANTITATIVE DETERMINATION PHENOL ALDEHYDE AND PHENOLIC ACIDS IN LIQUID DOSAGE FORM FOR EXTERNAL APPLICATION, CONTAINING PLANT EXTRACTS

Issue: 
8
Year: 
2016

Ya.F. Kopytko
Ph.D. (Pharm.), Leading Research Scientist, Department of Standardization and Certification,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)
E-mail: yanina@kopytko.ru
P.G. Mizina
Dr.Sc. (Pharm.), Professor, Deputy Director on Scientific Work,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants; Peoples’ Friendship University of Russia (Moscow)
E-mail: mizina-pg-@yandex.ru
P.M. Masese
Post-graduate Student, Peoples’ Friendship University of Russia (Moscow)
E-mail: pet_masese@yahoo.com
N.I. Sidelnikov
Dr.Sc. (Agrical.), Director, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)

Development of effective and safe antimicrobial, antiviral, wound healing and regenerative action, drugs of herbal origin is an important issue of Pharmacy. Among the substances for making such herbal medicines with broad pharmacological activities are: eucalimin and estifan. Eucalimin is derived from the leaves and shoots of eucalyptus (Eucaliptus viminalis Labill.) Sem. myrtle (Myrtaceae) and estifan − dry extract derived from the herb Echinacea purpurea (Echinacea purpurea) (L.) Moench .A liquid drug form (LDF) was made using the above mentioned herbal substances consisting of methylcellulose (MC) or sodium alginate as the base, for external use and methods of analysis were developed. This article presents results of developing standardization methods for identity tests and quantitative determination of phenolaldehydes and phenolcarbonic acids using spectrophotometry method for liquid dosage forms consisting of eucalimin and estifan.

Keywords: 
Key words: Eucalyptus viminalis
Echinacea purpurea
liquid dosage forms
LDF
evkalimin
estifan
quantification.