DRUG REGULATION OF GENE ACTIVITY
Issue:
9
Year:
2016
Today classic genocentric concept is radically overhauled, and new young scientific discipline of epigenetics, which studies the ability
to reverse the direction of the flow of information on the function, under the influence of various external and internal factors, the corresponding
gene is considered to be one of the most studied and perspective in biology. Epigenetic modification, also called epimutations,
unlike true genetic mutations do not affect the structure of the DNA and are potentially reversible, i.e. can be regulated by factors internal
and external environment. Especially actively examines the role of epigenetics in the initiation and progression of cancer, which led to the
formation of a separate, independent scientific direction − epigenetics of cancer. The reversibility of abnormal epigenetic modifications
makes enzymes that mediate the reversibility very attractive drug target in the development of targeted epigenetic drugs. Key targets are
considered to be a DNA methyltransferase and histone deacetylase. In view of the foregoing, we developed drugs Indinol® Forto (active
substance indole-3-carbinol) Epigallat® (active substance) and Cezarox® (diindolylmethane active substance in a liquid dosage form that
has greater bioavailability). According to clinical trials conducted by us in conjunction with specialists from the leading medical institutions
of the Russian Federation, high efficiency of these drugs has been proved as a means of mono- and combination therapy in the treatment
of various benign and precancerous diseases of the female reproductive system. Thus, in patients of reproductive age with benign (HPV infection)
and pre-cancerous (CIN 1-2) cervical disease after a 6-month course of therapy with Indinol® Forto and Epigallat®, there was
normalization of the clinical signs and almost a 100% demethylation of significant gene suppressors of tumor growth. Similar results were
obtained in another trial, during which we studied DNA demethylating activity of these two drugs in the treatment of patients with pathological
processes of the endometrium.
Keywords:
Key words: epigenetic; indole-3-carbinol; epigallocatechin-3-gallate; diindolylmethane; pre-cancerous diseases.