THE STUDY OF THE ABILITY OF A MULTI-COMPONENT COMPOSITION TO LOWER THE DEGREE OF ALCOHOL INTOXICATION IN LABORATORY RATS

Issue: 
11
Year: 
2016

N.V. Kochkina
Ph.D. (Biol.), Senior Research Scientist, Scientific Center «Signal» (Moscow)
E-mail: gniiivm-s@yandex.ru
E.A. Rud’ko
Ph.D. (Pharm.), Head of Department, Scientific Center «Signal» (Moscow)
A.V. Malinin
Dr.Sc. (Med.), Leading Research Scientist, Scientific Center «Signal» (Moscow)
S.V. Lamanova
Research Scientist, Scientific Center «Signal» (Moscow)
V.A. Maltseva
Junior Research Scientist, Scientific Center «Signal» (Moscow)

To restore human performance after alcohol intoxication, reducing after intoxication consequences, as well as to enhance the resilience of alcohol intoxication when receiving the ethanol-containing beverages, based on fenilpiratsetam, extract radiograms pink, pyridoxine hydrochloride, ascorbic acid and oil of peppermint has been developed a new multi-component composition, providing multidirectional action in the formation and sober hangover effect. In experiments on white mongrel male rats weighing 180-200 grams on an empty stomach with alcohol intoxication modeling moderate intragastric administration to rats of 30% ethyl alcohol solution at 0.5, 1, 2, 3 and 6 hours after administration of study medication or ethanol conducted a comprehensive numerical score of severity of intoxication manifestations on the basis of indicators of the situation and the nature of the motor activity of the animal in the cage at rest and after the manual treatment, the nature of reflex grasping and avoiding «Davis on a wire», respiratory rate, tactile and pain sensitivity. A series of experiments demonstrated that neuroprotective drugs fenilpiratsetam improves the condition of laboratory animals after alcohol intoxication, and the use of the developed integrated product, having in its composition nootropic component analeptic stimulants metabolism and adaptogen passed for 1 hour prior to the application of alcohol can reduce the degree of alcohol intoxication and expedite recovery from her body. The developed multi-component drug has great detoxifying effect and hangover activity compared to fenilpiratsetam. The most hangover and detoxifying activity was detected when using multicomponent compositions investigated for 1 hour before administration of ethanol, allowing to lower the degree of alcohol intoxication of medium to light weight.

Keywords: 
Key words: detoxification
alcohol intoxication
alcohol intoxication model
recovery from alcohol intake.