AMINO ACIDS ARE PRECURSORS ERGOT ALGALOIDS MOLECULES IN THE FUNCUS OF GENUS CLAVICEPS (REVIEW)

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Issue: 
1
Year: 
2017

R.I. Bobyleva
Ph.D. (Biol.), Leading Research Scientist, Biotechnology Section,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)
E-mail: vilarnii@mail.ru
T.A. Savina
Ph.D. (Biol.), Manager of Biotechnology Section,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)
E-mail: savina-tatyana57@yandex.ru

The present work describes ergot alkaloids (EA), possesing a marked physiological activity widely using in medicine. EA subdivide into 4 structural groups: ergot clavine type, simple derivatives of lysergic acid, peptides and lactam EA, nitrogen contained heterocycles, while amino acids being donators of nitrogen atoms. The peculiarity of EA are N-6-methyl-amino group in their molecules, donators of which are amino acid methionine. There are shown that classical EA contain proline in peptide part of molecule in all EA, and characteristic amino acids for definite structures. Amino acids in EA molecules play part not only as substrates. According to the published data tryptophan is the precursor of EA and both as an inducer and as derepressor for enzymes catalyzing the biosynthesis of EA.

Keywords: 
Key words: ergot alkaloids
Claviceps purpurea (Fries) Tulasne
amino acids.

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