THE INVESTIGATION OF THE ANTISEPTICS’ ANTIMICROBIAL ACTIVITY IN THE PRESENCE OF NANOSIZED CERIUM DIOXIDE

Issue: 
2
Year: 
2017

O.A. Legonkova Dr.Sc. (Eng.), Head of Department of Bandages, Sutures and Polymeric Materials in Surgery, A.V. Vishnevsky Institute of Surgery (Moscow) E-mail: Legonkova@ixv.ru R.P. Terekhova Ph.D. (Med.), Head of Laboratory of Prevention and Treatment of Bacterial Infections, A.V. Vishnevsky Institute of Surgery (Moscow) T.A. Ushakova Dr.Sc. (Med.), Head of Express Laboratory of Burn Center, A.V. Vishnevsky Institute of Surgery (Moscow) A.I. Korotaeva Junior Research Scientist, Department of Bandages, Sutures and Polymeric Materials in Surgery, A.V. Vishnevsky Institute of Surgery (Moscow) A.A. Alekseev Dr.Sc. (Med.), Professor, Director of the Burn Center, A.V. Vishnevsky Institute of Surgery (Moscow) M.A. Teplonogova Student, Lomonosov Moscow State University A.E. Baranchikov Ph.D. (Chem.), Head of Laboratory of Chemical Synergy, N.S. Kurnakov Institute of General and Inorganic Chemistry (Moscow) V.K. Ivanov Dr.Sc. (Chem.), Corresponding Member of RAS, Director of N.S. Kurnakov Institute of General and Inorganic Chemistry (Moscow)

The investigations of the antiseptics’ antimicrobial activity in the presence of nanosized cerium dioxide (NCD) in the purposes of dressings’ (coverings’) elaboration for wound treatment were carried out. It was found out that NCD solutions can be combined with any antiseptics without the suppression of their antimicrobic activity. The reduction of the antiseptics’ concentration twice doesn’t ef-fect on the antimicrobial activity of the NCD:antiseptic mixture, which allows to cut a consumption of antiseptics in case of medical de-vices. Neither stabilized nor unstabilized NCD have antimicrobial activity against clinical strain Staphylococcus epidermidis.

Keywords: 
Key words: nanosized cerium dioxide
antimicrobial activity
antiseptic
Lavasept
Chlorhexidine
Myramistin
cationic surfac-tants
Staphylococcus epidermidis.