THE EVALUATION OF THE ANTIOXIDANT ACTIVITY 4-HYDROXY-3,5-DITRETBUTIL CINNAMIC ACID, MEXIDOL AND THIOCTIC ACID AT THE MODEL OF BRAIN FOCAL ISCHEMIA

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Issue: 
2
Year: 
2017

A.V. Voronkov Dr.Sc. (Med.), Associate Professor, Pyatigorsk Medical and Pharmaceutical Institute − a Branch FSEI HE VolgFMU E-mail: prohor.77@mail.ru D.I. Pozdnyakov Post-graduate Student, Pyatigorsk Medical and Pharmaceutical Institute − a Branch FSEI HE VolgFMU E-mail: pozdniackow.dmitry@yandex.ru E.I. Khoury Post-graduate Student, Pyatigorsk Medical and Pharmaceutical Institute − a Branch FSEI HE VolgFMU E-mail: elena.belova@hotmail.ru Yu.E. Kulbekova Post-graduate Student, Pyatigorsk Medical and Pharmaceutical Institute − a Branch FSEI HE VolgFMU E-mail: kulbekoyu@mail.ru A.A. Kobin Lecturer, Pyatigorsk Medical and Pharmaceutical Institute − a Branch FSEI HE VolgFMU E-mail: kobin@inbox.ru

A study on the evaluation of the antioxidant activity of 4-hydroxy-3,5-ditretbutil cinnamic acid on the background of focal cere-bral ischemia of rats is done. The test compound is 4-hydroxy-3,5-ditretbutil cinnamic acid and comparison preparations mexidol and thioctic acid was administered immediately after the playback ischemia of the brain and throughout the 3-day, in the morning hours. After this time the animals were decapitated, the brain was extracted and was measured in the homogenate content malondialdehyde, and conjugated dienes, and in post-nuclear fractions of brain activity of superoxide dismutase, catalase and glutathione peroxidase. As a result, the study found that in terms of focal cerebral ischemia in rats experienced higher education pro-oxidants and a decrease in the activity of endogenous antioxidant defense enzymes. Introduction mexidol similar conditions contributed to the decline of educa-tion malondialdehyde and diene conjugates, as well as the restoration of the activity of antioxidant enzymes. Against the background of the introduction of the thioctic acid decreased the concentration of malondialdehyde and increased the activity of superoxide dismutase and catalase. With the introduction of 4-hydroxy-3,5-ditretbutil cinnamic acid in rats showed regeneration pro / antioxidant balance, which is reflected in the decrease in the concentration of malondialdehyde (by 52,6% (p < 0,05)), diene conjugates (88, 5% (p < 0,05)) and increasing the activity of catalase (to 1456% (p < 0,02)), superoxide dismutase (18- times (p < 0,05)) and glutathi-one peroxidase (4.1 times (p < 0.05)) in this case, on the antioxidant properties of 4-hydroxy-3,5-ditretbutil cinnamic acid is close to mexidol and exceeds thioctic acid

Keywords: 
Key words: antioxidants
mexidol
cerebral ischemia
thioctic acid
cinnamic acid derivatives.

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