THE INFLUENCE OF THE NON-ALCOHOLIC FATTY THE LIVER DISEASE ON THE TRACE ELEMENT CONTENT IN LIVER OF RATS

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Issue: 
4
Year: 
2017

E.R. Gatiatulina
Assistant, Department of Biochemistry, Orenburg State Medical University;
aspirant, South Ural State Medical University (Chelyabinsk)
E.V. Popova
Ph.D. (Med.), Associate Professor, Department of Biochemistry, Orenburg State Medical University
V.S. Polykova
Dr.Sc. (Med.), Professor, Orenburg State Medical University
А.А. Skalnaya
Student, Lomonosov Moscow State University
E.F. Agletdinov
Dr.Sc. (Med.), Professor, Bashkir State Medical University (Ufa)
E.A. Nikonorova
Assistant, Department of Medical Elementology, RUDN university (Moscow)
A.V. Skalny
Dr.Sc. (Med.), Professor, Institute of Bioelementology (Russian Satellite Centre of Trace Element – Institute for UNESCO),
Orenburg State University; P.G. Demidov Yaroslavl State University;
RUDN university; All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)
A.A. Tinkov
Ph.D. (Med.), Assistant, Department of Biochemistry, Orenburg State Medical University;
Institute of Bioelementology (Russian Satellite Centre of Trace Element – Institute for UNESCO),
Orenburg State University; P.G. Demidov Yaroslavl State University; RUDN university (Moscow)
E-mail: tinkov.a.a@gmail.com

The non-alcoholic fatty liver disease (NAFLD) is defined as hepatic manifestation of metabolic syndrome and considered to be the commonest liver disease in the world. Taking into account the role of trace elements in the pathogenesis of metabolic syndrome, obesity and hepatic diseases the influence of diet-induced non-alcoholic fatty liver disease on trace elements content in liver of rats was assessed. In total 56 female Wistar rats with equal body weight were used in the present experiment for 6 weeks. The animals were divided into two groups according to a feeding status: a control group of animals was fed a standard diet (10% calories from fat) whereas the rats from an experimental group were given high-calorie diet (HCD) (60% calories from fat in chow and 10% sucrose solution). The obtained data showed that NAFLD resulted in significant disturbances of the liver trace elements homeostasis in rats. High calorie feeding resulted in a significant decrease in hepatic Co, Cu, I, Li, Mn, Se, Zn levels. However, only Mn and Se levels remained reduced after the adjustment for total protein.

Keywords: 
fatty liver
steatosis
liver
trace elements
selenium
manganese.

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