THE SYSTEM OF THE INSULIN-LIKE GROWTH FACTORS IN THE MALIGNANT NEOPLASMS OF OVARIES

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Issue: 
8
Year: 
2017

N.E. Kushlinskii
Dr.Sc. (Med.), Professor, Member-Correspondent of Russian Academy of Sciences, Head of Clinical Biochemistry Laboratory,
N.N. Blokhin Russian Cancer Research Center Ministry of Health of Russian Federation (Moscow)
E-mail: biochimia@yandex.ru
E.S. Gershtein
Dr.Sc. (Biol.), Professor, Laboratory of Clinical Biochemistry,
N.N. Blokhin Russian Cancer Research Center Ministry of Health of Russian Federation (Moscow)
V.D. Ermilova
Ph.D. (Med.), Leading Research Scientist,
N.N. Blokhin Russian Cancer Research Center Ministry of Health of Russian Federation (Moscow)
D.N. Kushlinsky
Ph.D. (Med.), oncogynecologist, N.N. Blokhin Russian Cancer Research Center Ministry of Health of Russian Federation (Moscow)
S.V. Khokhlova
Dr.Sc. (Med.), Senior Research Scientist, N.N. Blokhin Russian Cancer Research Center Ministry of Health of Russian Federation (Moscow)
Y.Z. Plieva
Gynecologist, Moscow State University of Medicine and Dentistry named after A.I. Evdokimov of Russian Federation (Moscow)
I.V. Tereshkina
Ph.D. (Med.), Moscow State University of Medicine and Dentistry named after A.I. Evdokimov of Russian Federation (Moscow)
N.A. Ognerubov
Dr.Sc. (Med.), Professor, Head of Oncology, Operative Surgery and Topographical Anatomy Department,
Tambov State University named after G.R. Derzhavin of Russian Federation (Tambov)
E-mail: ognerubov_n.a.@mail.ru

The analysis of the modern literature data and the results of our own studies of the clinical significance of the system of the insulin- like growth factors (IGF) (receptors, ligands, IGF-binding proteins in blood serum) in norm and in patients with various ovarian neoplasms is presented. The connection of the key components of the IGF system with the development of ovarian cancer, the prognosis of the disease and the possibility of anti-IGF therapy in the treatment of these patients are discussed.

Keywords: 
IGF
IGFBP
ovarian cancer.

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