ANTIHYPOXIC ACTIVITY OF CIMICIFUGA DAHURICA TINCTURE

Issue: 
9
Year: 
2017

Ya.G. Razuvaeva Dr.Sc. (Biol.), Senior Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude); Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education (Irkutsk) E-mail: tatur75@mail.ru A.A. Toropova Ph.D. (Biol.), Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude) D.E. Garmaev Post-graduate Student, Institute of General and Experimental Biology SB RAS (Ulan-Ude)

The aim of the study is to estimate antihypoxic activity of the tincture from Cimicifuga dahurica. The experiments were carried out on white Wistar rats. The results have shown that the tincture from C. dahurica extends life span in animals with hypoxic hypoxia (by 24-32%), hemic hypoxia (by 16%) and histotoxic hypoxia (by 18-36%). In hypoxia/reoxygenation conditions the tincture at a dose of 1.0 ml/kg decreases the MDA content (by 1.7 times), increases the catalase activity (by 29%) and the GSH content (by 31%) in the brain homogenate of white rats. The tincture from C. dahurica increases the ATP concentration (by 2.1 times), decreases the lactate content (by 32%) in the brain homogenate of white rats with hypoxia/reoxygenation. Thus, the C. dahurica tincture has the an-tihypoxic activity, decreases the manifestation of free radical oxidation processes, increases the activity of the endogen antioxidant system; as well it improves the efficiency of the coupling of tissue breathing and oxidative phosphorylation in the brain under hypox-ia/reoxygenation conditions.

Keywords: 
Key words: tincture of Cimicifuga dahurica
hypoxia
antihypoxic activity
free radical oxidation
endogen antioxidant system
oxidative phosphorylation.