PROANGIOGENIC FACTORS IN RENAL CANCER: VEGF FAMILY AND ITS RECEPTORS, MECHANISMS OF ACTION

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Issue: 
9
Year: 
2017

N.E. Kushlinskii Dr.Sc. (Med.), Professor, Member-Correspondent of Russian Academy of Sciences, Head of Clinical Biochemistry Laboratory, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation (Moscow) E-mail: biochimia@yandex.ru, E.S. Gershtein Dr.Sc. (Biol.), Professor, Laboratory of Clinical Biochemistry, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation (Moscow), A.V. Kolpakov applicant, the Department of Clinical Biochemistry and Laboratory Diagnostics, Moscow State Medico-Stomatological University after name A.I. Evdokimov (Moscow), A.A. Morozov applicant, the Department of Clinical Biochemistry and Laboratory Diagnostics Moscow State Medico-Stomatological University after name A.I. Evdokimov (Moscow) , O.I. Kostyleva PH.D. (Med.), senior scientist, Laboratory of Clinical Biochemistry, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation (Moscow) A.A. Alferov Post-graduate Student, the Department of Clinical Biochemistry and Laboratory Diagnostics Moscow State Medico-Stomatological University after name A.I. Evdokimov (Moscow) , M.V. Fridman Ph.D. (Biol.), Institute of General Genetics after name N.A. Vavilov of the RAS (Moscow)

Angiogenesis − a complicated morphogenetic process of new capillaries formation from pre-existing blood vessels - is a compul-sory constituent of tumor development and progression. Investigation of the molecular mechanisms of this process revealed a wide spectrum of regulatory pro- and antiangiogenic molecules, which dynamic balance guarantees the proper formation and extension of new vessels inside the tumor. In this review, the main investigation stages and established mechanisms of tumor angiogenesis are de-scribed, and a detailed characteristic of its key positive regulator vascular endothelial growth factor (VEGF) and the mechanisms of its action through specific receptors are presented. Contemporary methods of evaluation of tumor angiogenesis activity are analyzed with special emphasis on the study of renal-cell cancer taking into consideration that an important role in its development belongs to inacti-vating mutation in tumor-suppressor gene VHL.

Keywords: 
Key words: VEGF
VEGFR
VHL
neoangiogenesis
renal cell carcinoma .

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