THE MECHANISMS OF A PROTECTIVE ACTION OF COENZYME Q10 IN EXPERIMENTAL THERMAL INJURY

Download full text PDF
Issue: 
10
Year: 
2017

A.G. Soloveva Ph.D. (Biol.), Senior Research Scientist, Privolzhsky Federal Research Medical Centre (Nizhny Novgorod) E-mail: sannag5@mail.ru A.A. Ulanova Ph.D. (Biol.), Senior Research Scientist, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) E.I. Kuzmina Ph.D. (Biol.), Associate Professor, Nizhny Novgorod State Medical Academy V.L. Kuznetsova Ph.D. (Biol.), Research Scientist, Privolzhsky Federal Research Medical Centre (Nizhny Novgorod)

For the correction of metabolic disorders in patients with severe burns natural antioxidant ubiquinone (coenzyme Q10) can be used. However, today, there are not enough sources showing of its corrective capabilities in thermal injury. The aim of the work was to study the effect of ubiquinone on the energy metabolism, pro- and antioxidant blood systems in experimental thermal injury. Mate-rials and methods. The experiment was conducted on 30 Wistar rats. The animals were divided into 3 groups: 1 – intact healthy rats, 2 – control with burn, 3 – experiment with burn animals who daily received ubiquinone (15 mg/kg). The method of induced bio-chemiluminescence was used for the estimation of lipid peroxidation and total antioxidant activity. The concentration of glucose, lac-tate and malonic dialdehyde, the activity of catalase, superoxide dismutase, lactate dehydrogenase were determined in the blood. Re-sults. The increase of lipid peroxidation on the background of decrease of antioxidant reserves was marked in animals with thermal trauma, it led to the development of oxidative stress. During the burn it was revealed the violation of carbohydrate metabolism, mani-fested in the accumulation of lactate and increase of glucose. It installed that the use of ubiquinone in complex treatment of experi-mental thermal injury led to a decrease in the intensity of free radical processes in plasma and erythrocytes of rats, the increase in general and enzymatic antioxidant activity, normalization of lactate concentration and specific activity of lactate dehydrogenase. Con-clusion. The received results are the pathogenetic rationale for the use of ubiquinone in complex therapy of thermal injury.

Keywords: 
thermal injury
lipid peroxidation
glucose
lactate
coenzyme Q10.

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.