THE STUDY OF POSTNATAL DEVELOPMENT OF RATS OFFSPRING BORN FROM MOTHERS TREATED WITH LYCOPUS EUROPAEUS DURING PREGNANCY

Issue: 
11
Year: 
2017

L.V. Krepkova
Ph.D. (Biol.), Head of Toxicology Department, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)
Е-mail: krepkowa2011@yandex.ru
T.V. Savinova
Ph.D. (Biol.), Leading Research Scientist, Toxicology Department,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)
Е-mail: tamarasavinova@yandex.ru
V.V. Bortnikova
Ph.D. (Biol.), Leading Research Scientist, Toxicology Department,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)
E-mail: bortnikova.v@yandex.ru
M.V. Воrovkova
Senior Research Scientist, Toxicology Department, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)
Е-mail: borovkova_65@mail.ru
O.S. Kuzina
Senior Research Scientist, Toxicology Department, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)
E-mail: oskt@list.ru

The influence of Lycopus europaeus dry extract – thyreostatic on of postnatal development of rats offspring were studied. Lycopus dry extract introduced into the stomach rats at doses of 50, 250 and 750 mg/kg during pregnancy (1–19 days). The physical parametrs development of rats offspring: eye opening, tests invertion on the plane and in free fall and etc. were studied. It was shown that Lycopus extract did not affect survival, the body weight of rats offspring (from 1 to 21 days of life) and the formation of sensorymotor reflexes. Lycopus dry extract at doses 250 and 750 mg/kg penetrated through the placenta and caused the 30-day-old rats hypotrophy of the thyroid gland. The drugs on the basis of dry extract of Lycopus may be administered during pregnancy only under medical supervision in recommended therapeutic doses (6–8 mg/kg), and also in the case when the expected benefits exceed the possible risks to the fetus.

Keywords: 
Lycopus europaeus
dry extract
thyreostatic
rats
postnatal period of development.