OPTICAL MOLECULAR ANALYSIS OF PHARMACEUTICAL PREPARATIONS USING OFFICE FLATBED SCANNER: FLUORIMETRY AND NEPHELOMETRY

Issue: 
11
Year: 
2017

K.V. Oskolok
Ph.D. (Chem.), Associate Professor, Department of Analytical Chemistry, Faculty of Chemistry, Lomonosov Moscow State University
E.V. Shultz
Student, Faculty of Chemistry, Lomonosov Moscow State University
O.V. Monogarova
Ph.D. (Chem.), Associate Professor, Department of Analytical Chemistry, Faculty of Chemistry, Lomonosov Moscow State University
A.A. Chaplenko
Post-graduate Student, Department of Analytical Chemistry, Faculty of Chemistry, Lomonosov Moscow State University;
Expert, Scientific Center on Expertise of Medical Application Products of Ministry of Health of Russia
E-mail: a.a.chaplenko@yandex.ru

This paper describes the design and principles of using of office flatbed scanner equipped with a slide-adapter for fluorimetric and nephelometric determination of active ingredients in pharmaceutical preparations. The radiation source used in this paper is the household violet laser. The possibility of using the scanner for measuring fluorescence spectrum with a linear absorption of optical filters with variable bandwidth obtained by the method of inkjet printing on a polymer film. New technical approaches and solutions proposed in this article can be used in pharmaceutical laboratories to conduct preclinical bioanalytical studies, in screening of drugs quality. Scientific novelty of the conducted research relates to the development of analytical complex based on flatbed scanner. The authors developed office flatbed scanner for fluorimetric and nephelometric analyses of pharmaceuticals. There has been showed fundamental possibility of measurement of fluorescence using a flatbed scanner. The effeciency of the proposed technical solutions is confirmed by the results of the determination of Riboflavin in injectable solution of Riboflavin mononucleotide® and magnesium in a drug Cardiomagnyl®.

Keywords: 
fluorimetry
nephelometry
digital optical analysis
drug analysis.