THE PHARMACEUTICAL AND ECOLOGICAL ASPECTS OF USE OF GRAINS AS A SOURCE OF PECTINS

Issue: 
12
Year: 
2017

N.S. Kajsheva
Dr.Sc. (Pharm.), Professor, Department of Pharmaceutical and Toxicological Chemistry,
Pyatigorsk Medic-Pharmaceutical Institute - Branch FGBOU VO of the «Volgograd State Medical University»
Ministries of Health of the Russian Federation
E-mail: caisheva2010@yandex.ru
A.S. Kajshev
Ph.D. (Pharm.), Leading Specialist, Inter-Regional Rosalkogolregulirovaniya Office for North Caucasian Federal District (Essentuki)
E-mail: kaishev2010@yandex.ru
V.A. Mikelov
Post-graduate Student, Department of Pharmaceutical and Toxicological Chemistry,
Pyatigorsk Medic-Pharmaceutical Institute - Branch FGBOU VO of the «Volgograd State Medical University»
Ministries of Health of the Russian Federation, A.B. Samoryadova
Ph.D. (Pharm.), Associate Professor, Department of Pharmaceutical and Toxicological Chemistry,
Pyatigorsk Medic-Pharmaceutical Institute - Branch FGBOU VO of the «Volgograd State Medical University»
Ministries of Health of the Russian Federation
E-mail: pharmachemistry@mail.ru

The aim of the study was the experimental substantiation of the pharmaceutical use of pectin from the grains and reduction of the toxicity index of industrial effluents − «chemical oxygen demand (COD)». From the solid and liquid phases of the wheat grains, the target products are identified, which are identified as pectins by spectroscopy and sedimentation reactions. Using the methods of potentiometry, gravimetry, viscometry, complexometry, physicochemical characteristics of pectins are established. The biological tests of pectins were carried out in experiments on rats according to tests: acute toxicity, hepatotoxicity, antiulcer action, acidity of gastric juice, evacuation function of the intestine. The value of COD of grains is determined by the method of dichromatometry. An isolation of pectin from the sardine leads to a 1.6 fold decrease in COD. The pectins are characterized by low average of the molar mass, a low water solubility, a high carboxyl group content and a degree of esterification, effective binding ability to lead (II) ions. The resulting pectins are practically non-toxic, exhibit antiulcer activity, normalizing effect on the acidity of gastric juice, inhibitory effect on intestinal motility.

Keywords: 
cereal grains
pectin
physico-chemical properties
biological activity.