PERSPECTIVES AND POSSIBILITIES OF APPLICATION OF DERIVATIVE POLYVINYLPYRROLIDONE IN PARASITIC DISEASES (REVIEW)

DOI: https://doi.org/10.29296/25877313-2019-10-01
Issue: 
10
Year: 
2019

A.V. Aydakova Post-graduate Student, Department of Biotechnology and Industrial Pharmacy, MIREA – Russian University of Technology (Moscow) D.O. Shatalov Ph.D. (Pharm.), Associate Professor, Department of Biotechnology and Industrial Pharmacy, MIREA – Russian University of Technology; Deputy General Director, Institute of Pharmaceutical Technologies JSC (Moscow) E-mail: shat-05@mail.ru S.A. Kedik Dr.Sc. (Eng.), Professor, Head of the Department of Biotechnology and Industrial Pharmacy, MIREA – Russian University of Technology; General Director, Institute of Pharmaceutical Technologies (Moscow) A.M. Tverdokhlebova Student, MIREA – Russian University of Technology (Moscow) P.Y. Demenyuk Student, MIREA – Russian University of Technology (Moscow) E-mail: iitw@yandex.ru S.V. Belyakov Post-graduate Student, Department of Biotechnology and Industrial Pharmacy, MIREA – Russian University of Technology (Moscow) I.S. Ivanov Post-graduate Student, Department of Biotechnology and Industrial Pharmacy, MIREA – Russian University of Technology (Moscow) I.V. Bogunova Assistant, Department of Biotechnology and Industrial Pharmacy, MIREA – Russian Technological University (Moscow) A.V. Aksenov Dr.Sc. (Chem.), Professor, Head of the Department Chemistry, North-Caucasus Federal University (Stavropol) A.I. Gromakova Dr.Sc. (Pharm.), Chief Researcher of the Scientific and Organizational Department, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) K.S. Evstafieva Student, Institute of Physics, Technology, and Informational Systems, Moscow Pedagogical State University (Moscow)

This article provides information on the most frequently encountered parasitic diseases. Classification and clinical picture of the course of each type of disease, such as teniasis, cysticercosis, trichinosis, echinococcosis, alveococcosis as well as their diagnosis and necessary prevention. Possible methods of treatment of diseases caused by helminthiases, as well as the types of drugs that can be used for this. The treatment of parasitic diseases to date remains an urgent problem of modern medicine. Its goal is the eradication of the parasite and the elimination of the clinical manifestations of invasion. The use of etiotropic treatment often leads to a massive breakdown of parasites and the absorption of degradation products into the bloodstream, which can lead to increased toxicity and body sensitization. The aim of the development is to obtain the drug in the form of a solid dosage form for oral administration based on an innovative biologically active synthetic copolymer of vinylpyridine series. The novelty of the proposed approach to the treatment of the above diseases lies in the fact that it is aimed at activating "dormant" phagocytic cells, which, among other things, are part of the parasite tissue membranes. According to the results of animal studies (white rats and white mice, guinea pigs, ferrets), it was shown that the inclusion of such a copolymer in vaccines provides a higher immunogenic activity, unlike vaccines without using a copolymer. Copolymers of N-vinylpyrrolidone with 2-methyl-5-vinylpyridine have a number of unique properties, such as high hydrophilicity, which makes it easy to be absorbed from the gastrointestinal tract, the ability to complex, good adhesion to biological tissues, as well as its own biological activity - including due to the action of the links of the second comonomer, which leads to activation of the host macrophages and the ability to affect not only the mature helminth, but also the oncosphere and Finn shells during extraintestinal invasions, the lack of toxicity allows you to take long-term drugs containing this substance, without showing significant side effects observed in drugs used in anthelmintic therapy at the present time. This allows the use of such copolymers for various purposes in the pharmaceutical industry.

Keywords: 
copolymer of vinylpyridine
copolymer of N-vinylpyrrolidone and 2-methyl-5-vinylpyridine
helminthoses

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