FLAKOZID – DRUG FROM THE LEAVES OF PHELLODENDRON AMURENSE RUPR., IN TREATMENT OF DISEASES OF THE HEPATOBILIARY SYSTEM

DOI: https://doi.org/10.29296/25877313-2020-02-03
Issue: 
2
Year: 
2020

V.V. Bortnikova Ph.D. (Biol.), Leading Research Scientist, Department of Toxicology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) E-mail: bortnikova.v@yandex.ru V.V. Karabaeva Senior Research Scientist, Department of Experimental and Clinical Pharmacology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) E-mail: vera-karabaeva@rambler.ru L.V. Krepkova Ph.D. (Biol.), Head of Toxicology Department, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) E-mail: krepkowa2011@yandex.ru G.F. Sidelnikovа Research Scientist, Department of Experimental and Clinical Pharmacology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) P.G. Mizina Dr.Sc. (Pharm.), Professor, Deputy Director, All-Russian Research Institute of Medicinal and Aromatic Plants (Moscow) E-mail: mizina-pg@yandex.ru О.N. Karabaeva Student, Medical Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokimov E-mail: vera-karabaeva@rambler.ru

The aim: to show the effectiveness of the drug Flakozid, which has a broad spectrum of antiviral action in combination with a hepatoprotective effect, in the treatment of diseases of the hepatobiliary system. Material and Methods. The analysis of the effectiveness of the drug has been carried out based on the results of clinical studies of Flakozid, pre-sented by Russian clinical institutions. Results. With chronic hepatitis and cirrhosis of the liver, unconjugated hyperbilirubinemia and fatty liver, the use of oral Flakozid in daily doses of 0.3-0.6 g for 25-45 days has led to an improvement in the general condition of patients, reduction of pain in the right hypochondrium, reduction of dyspep-tic disorders, reduce the effects of asthenia, increase physical and intellectual performance, improve appetite. Noted a decrease in the level of total bil-irubin and the normalization of the level of ALAT, ASAT and alkaline phosphatase. According to cholecystography, the concentration and contractility of the gallbladder improved. In terms of the severity of the therapeutic effect, Flakozid was not inferior to Silibour and Karsil, and in some indicators (im-provement in motility of the gallbladder and biliary tract) markedly exceeded them. Conclusions. According to the results of clinical studies, it has been established that treatment of Flakozid has improved the functional state of the liver, reducing the syndrome of cytolysis and cholestasis. Flakozid has recommended in clinical practice in the complex treatment of diseases of the hepatobiliary system, such as CAG, chronic persistent hepatitis, chronic stoneless cholecystitis at the stage of subcompensation and decompensa-tion.

Keywords: 
flakozid
chronic hepatitis
chronic stoneless cholecystitis
fatty liver disease

References: 
  1. Gastroenterologiya: Spravoch. izdanie / Pod red. I.N. Denisova. M.: Eksmo. 2010. 558 s.
  2. Gastroenterologiya. Nacional'noe rukovodstvo: Kratkoe izdanie / Pod red. V.T. Ivashkina, T.L. Lapinoj. M.: GEOTAR-Media. 2015. 480 s.
  3. Fateeva T.V., Deryabin P.G., Bortnikova V.V., Krepkova L.V., Mizina P.G. Aktivnost' flakozida pri virusnom gepatite S v eksperimentah in vitro. Byulleten' eksperimental'noj biologii i mediciny. 2019. № 4. S. 463466.
  4. Bortnikova V.V., Krepkova L.V. Eksperimental'noe tok-sikologicheskoe izuchenie protivovirusnogo fitoprepara-ta flakozid. Vestnik Rossijskogo universiteta druzhby narodov (RUDN). 2008. № 7. S. 9295.
  5. Vichkanova S.A., Baginskaya A.I., Shipulina L.D. Kolhir V.K., Bortnikova V.V., Gorodnyuk T.I. Flakozid – effektivnoe rastitel'noe sredstvo dlya lecheniya gepatitov virusnoj i ne virusnoj etiologii, a takzhe virusnyh porazhenij kozhi. Sb. nauch. trudov VILAR: himiya, tekhnologiya, medicina. 2000.
  6. S. 316323.
  7. Vichkanova S.A., Kolhir V.K., Sokol'skaya T.A., Voskobojnikova I.V., Bykov V.A. Lekarstvennye sredstva iz rastenij. M. 2009. 431 s.
  8. Bortnikova V.V., Krepkova L.V., Arzamascev E.V., Kuzne-cov YU.B., Borovkova M.V. Protivovospalitel'nye svojstva nekotoryh rastitel'nyh antimikrobnyh i protivo-virusnyh preparatov. Sb. nauch. trudov, posvyashch. 70-letiyu Vserossijskogo nauchno-issledovatel'skogo instituta lekarstvennyh i aromaticheskih rastenij «Himiya, Tekhnologiya, Medicina». M. 2000. S. 369375