Нажмите на эту строку чтобы перейти к Новостям сайта "Русский врач"

Перейти
на сайт
журнала
"Врач"
Перейти на сайт журнала "Медицинская сестра"
Перейти на сайт журнала "Фармация"
Перейти на сайт журнала "Молекулярная медицина"
Перейти на сайт журнала "Вопросы биологической, медицинской и фармацевтической химии"
Журнал включен в российские и международные библиотечные и реферативные базы данных

ВАК (Россия)
РИНЦ (Россия)
Эко-Вектор (Россия)

INFLUENCE OF MULTIPLE VITAMIN DEFICIENCY ON THE MINERAL STATUS AND SOME RAT BLOOD INDICATORS

DOI: https://doi.org/10.29296/25877313-2020-03-06
Download full text PDF
Issue: 
3
Year: 
2020

N.A. Beketova Ph.D. (Chem.) Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow) O.A. Vrzhesinskaya Ph.D. (Biol.), Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow) V.M. Kodentsova Dr.Sc. (Biol.), Professor, E-mail: kodentsova@ion.ru O.V. Kosheleva Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow) L.V. Shevyakova Ph.D. (Biol.), Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow) S.N. Leonenko Post-graduate Student, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow) S.J. Soto Ph.D. (Med.), Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow) A.A. Sokolnikov Ph.D. (Biol.), Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow)

Insufficient intake of vitamins of group B and vitamin D is typical for the population of Russia. Data on disturb of mineral status and redistribution of trace elements in rat organs and tissues under deficiency of B vitamins had been appeared. The aim of the study was to characterize the effect of multiple vitamin deficiency in growing rats on the mineral status and some blood parameters. Material and methods. Multiple vitamin deficiency in Wistar male rats (n = 12) with an initial body weight (51.4 ± 0.5) was caused by a 5-fold de-crease in the vitamin content in the vitamin mixture of a semi-synthetic diet for 23 days. Animals of the control group (n = 12) received a full semi-synthetic diet. The concentration of vitamins A in blood plasma and lyophilized liver and the whole brain of rats was de-termined by HPLC, vitamins B1 and B2 in the liver, brain, urine and 4-pyridoxic acid in urine fluorimetric method. The content of minerals in the liver and brain was determined by the atomic absorption method. Results. Multiple vitamin deficiency was accompanied by a decrease copper by 6.8 times and magnesium by 26.9%, in the brain, and increase of 11.6% in calcium, an increase of the blood plasma concentration of calcium, protein and phosphorus in the by 2.96.9%, creatinine  by 20.3%, a 2.2-fold increase of the ratio of γ- and α-tocopherols (due to an increase of 1.5 times the concentration of γ-tocopherol), an increase in the De Ritis ratio by 32.9%. Conclusions. Multiple vitamin deficiency affects the redistribution of minerals in organs, which justifies the need to maintain the vitamin status at the optimal level and confirms the benefits of using vitamin-mineral complexes containing not only a complete set of vitamins, but also deficient minerals and trace elements.

Keywords: 
multiple vitamin deficiency
vitamin-mineral status
blood plasma
liver
brain
rats

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Kodentsova V.M., Beketova N.A., Nikityuk D.B., Tutel'yan V.A. Harakteristika obespechennosti vitaminami vzroslogo naseleniya Rossijskoj Federacii. Profilakticheskaya medicina. 2018; 21(4):3237. doi: 10.17116/profmed201821432.
  2. Rosanoff A., Dai Q., Shapses S.A. Essential nutrient interactions: does low or suboptimal magnesium status interact with vitamin D and/or calcium status? Adv. Nutr. 2016; 7(1): 25–43. doi:10.3945/an.115.008631.
  3. Apryatin S.A., Beketova N.A., Vrzhesinskaya O.A., Riger N.A., Evstratova V.S., Trusov N.V., Soto J.S., Mzhel'skaya K.V., Shumakova A.A., Kodencova V.M., Gmoshinskij I.V. Vliyanie V-vitaminnogo deficita na biohimicheskie, immunologicheskie pokazateli i mikroelementnyj status krys i myshej razlichnyh linij. Voprosy pitaniya. 2018; 87(4):14–24. doi:10.24411/0042-8833-2018-10037.
  4. Apryatin S.A, Shumakova A.A., Vrzhesinskaya O.A., Leonenko S.N., Kodentsova V.M., Gmoshinski I.V. Alteration of mineral element status of rodents under combined group B vitamin deficiency. Trace Elements and Electrolytes. 2018; 35(4): 193-195. doi:10.5414/TEX0155405.
  5. Kodentsova V.M., Vrzhesinskaya O.A., Beketova N.A., Soto S.J., Karagodina Z.V., Bessonov V.V. Mikroelementnyj i antioksidantnyj status krys pri poligipovitaminoze. Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2013; 2:064068.
  6. Reeves P.G. Components of the AIN-93 diets as improvements in the AIN-76A diet. J. Nutr. 1997; 127(5 Suppl): 838S-841S.
  7. doi: 10.1093/jn/127.5.838S.
  8. Kodentsova V.M., Beketova N.A., Vrzhesinskaya O.A. Vitaminnyj sostav eksperimental'nyh racionov krys. Voprosy pitaniya. 2012; 81(4):6570.
  9. Vrzhesinskaya O.A., Kodentsova V.M., Beketova N.A., Pereverzeva O.G., Kosheleva O.V. Eksperimental'naya model' alimentarnogo poligipovitaminoza raznoj stepeni glubiny u krys. Voprosy pitaniya. 2012; 81(2):5156.
  10. Shinpo K., Kikuchi S., Sasaki H., Moriwaka, F., Tashiro K. Effect of 1,25-dihydroxyvitamin D3 on cultured mesencephalic dopaminergic neurons to the combined toxicity caused by L-buthionine sulfoximine and 1-methyl-4-phenylpyridine. J. Neurosci. Res. 2000; 62(3):374382.
  11. Brewer L.D., Thibault V., Chen K.C., Langub M.C., Landfield P.W., Porter N.M. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J. Neurosci. 2001; 21(1): 98108.
  12. Kaluev A.V., Eremin K.O., Tuohima P. Mekhanizmy nejroprotektornogo dejstviya vitamina D3. Biohimiya. 2004; 69(7):907–911.
  13. Boehm O., Zur B., Koch A., Tran N., Freyenhagen R., Hartmann M., Zacharowski K. Clinical chemistry reference database for Wistar rats and C57/BL6 mice. Biol. Chem. 2007; 388(5):547554.
  14. Kodentsova V.M., Risnik D.V. Tokoferoly: funkcional'naya rol', kriterii obespechennosti, potrebnost' i rekomenduemoe potreblenie Voprosy dietologii. 2018; 8(2): 2–31. doi:10.20953/2224-5448-2018-2-22-31.
  15. Trusov N.V., Guseva G.V., Beketova N.A., Aksenov I.V., Avren'eva L.I., Kravchenko L.V. Vliyanie deficita vitaminov v racione krys na inducibel'nost' citohroma R45. Voprosy pitaniya. 2014; 83(3):411.
  16. Traber M.G. Mechanisms for the prevention of vitamin E excess. J. Lipid. Res. 2013; 54(9):2295–2306. doi:10.1194/jlr.R032946.
  17. Jiang Q. Natural forms of Vitamin E: metabolism, antioxidant and antiinflammatory activities and the role in disease prevention and therapy. Free Radic. Biol. Med. 2014; 72:76–90. doi:10.1016/j.freeradbiomed.2014.03.035.