ЛЕКАРСТВЕННОЕ ЛЕЧЕНИЕ БОЛЬНЫХ РАКОМ ЯИЧНИКОВ ЧАСТЬ 2. АНТИАНГИОГЕННЫЕ ПРЕПАРАТЫ, ИХ СОЧЕТАНИЕ С ТАКСАНАМИ И ПРОИЗВОДНЫМИ ПЛАТИНЫ В ЛЕЧЕНИИ БОЛЬНЫХ РАКОМ ЯИЧНИКОВ: ОСНОВНЫЕ ПРИНЦИПЫ ТЕРАПИИ РЕЦИДИВОВ

DOI: https://doi.org/10.29296/25877313-2018-08-03
Номер журнала: 
8
Год издания: 
2018

С.В. Хохлова д.м.н., ст. науч. сотрудник, отделение химиотерапии, ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России (Москва) E-mail: svkhokhlova@mail.ru Д.Н. Кушлинский к.м.н., онкогинеколог, отделение инновационной онкологии и гинекологии, ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. В.И. Кулакова» Минздрава России (Москва)

Представлены современные данные зарубежной и отечественной литературы, отражающие лекарственное лечение больных раком яичников. Проанализированы различные режимы антиангиогенной терапии, дана характеристика ключевых мишеней антиангиогенных препаратов (VEGF, VEGFR1-3), рассмотрены их эффективность и токсичность, сочетание в различных комбинациях с таксанами и производными платины, роль маркера СА-125 в оценке эффективности лечения у больных раком яичников. Приведены основные принципы лечения рецидивов у больных раком яичников, а также классификация рецидивов. Особое внимание уделено лекарственной терапии платиночувствительных рецидивов рака яичников.

Ключевые слова: 
рак яичников
антиангиогенная терапия
классификация рецидивов
платиночувствительные рецидивы
лечение

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