Download full text PDF

R.P. Terekhov Student, Sechenov University (Moscow); Fraunhofer Institute for Cell Therapy and Immunology IZI (Leipzig, Germany) E-mail: I.A. Selivanova Dr. Sc. (Pharm.), Professor, Sechenov University (Moscow) E-mail:

Dihydroquercrtin (DHQ) - 2,3-dihydro-3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyranone-4, also known as taxifolin is the major flavonoid of the larix wood with a wide range of pharmacological activities which is combined with the absence of embriotoxicity, teratogenecity and mutability. However, industrially isolated DHQ is slightly soluble in water at room temperature and therefore has a limited bioavailability. This circumstance restricts the clinical use of dihydroquercrtin. In this study the lyophilization with different co-formers (vanillin, cinnamaldehyde, benzaldehyde, urea, and nicotinic acid) was used to improve the water-solubility of DHQ. The logarithmic correlation between fractal dimensions of solid structures and solubility of DHQ lyophilisats was established during the fractal analysis of photomicrographs by using of FDim software. The correlation coefficient was 0.89. The Relative standard deviation was not more than 1.75%. These results showed that fractal analysis can be used in the pharmaceutical industry as a promising method for rapid, automatic monitoring of quality control of pharmaceutical active ingredients without any substances loss.

dihydroquercetin (taxifolin)
fractal analysis
lyophilized form
solubility in water

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

  1. Basak U.K., Datta A. Fractal dimension and complexity in the long-term dynamics of a monomolecular layer // Chaos Soliton. Fractals. 2015. № 81. R. 534−541.
  2. Peng X., Qi W., Su R. et al. Describing some characters of serine proteinase using fractal analysis // Chaos Soliton Fractals. 2012. V. 45, № 7. R. 1017−1023.
  3. Gabriel-Guzmán M., Rivera V.M., Cocotle-Ronzón Y. et al. Fractality in coffee bean surface for roasting process // Chaos Soliton. Fractals. 2017. № 99. R. 79−84.
  4. Hurychová H., Kuentz M., Šklubalová Z. Fractal aspects of static and dynamic flow properties of pharmaceutical excipients // J. Pharm. Innov. 2017. 017-9302-0.
  5. Schauss A.G., Tselyco S.S., Kuznetsova V.A. et al. Toxicological and genotoxicity assessment of a dihydroquercetin-rich Dahurian Larch tree (Larix gmelinii Rupr) extract (Lavitol) // Int. J. Toxicol. 2015. V. 34. № 2. R. 162−181.
  6. Plotnikov M.B., Tjukavkina N.A., Plotnikova T.M. Lekarstvennye preparaty na osnove digidrokvertsetina // Tomsk: Tomskij universitet. 2005. 228 s. (Plotnikov M.B., Tjukavkina N.A., Plotnikova T.M. Lekarstvennye preparaty na osnove digidrokvercetina // Tomsk: Tomskij
  7. universitet. 2005. 228 s. [In Russ.]).
  8. Reuter M. FDim – Fractal Dimension. [software]. Rezhim dostupa: (data obraschenija 22 marta 2017) (Reuter M. FDim – Fractal Dimension. [software]. Rezhim dostupa: fdim/ (data obrashhenija 22 marta 2017)).