THE FRACTAL ANALYSIS OF DIHYDROQUERCETIN OF THE LYOPHILIZED FORMS

DOI: https://doi.org/10.29296/25877313-2018-03-03
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Issue: 
3
Year: 
2018

R.P. Terekhov Student, Sechenov University (Moscow); Fraunhofer Institute for Cell Therapy and Immunology IZI (Leipzig, Germany) E-mail: r.p.terekhov@yandex.ru I.A. Selivanova Dr. Sc. (Pharm.), Professor, Sechenov University (Moscow) E-mail: irinaselivanova@yandex.ru

Dihydroquercrtin (DHQ) - 2,3-dihydro-3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyranone-4, also known as taxifolin is the major flavonoid of the larix wood with a wide range of pharmacological activities which is combined with the absence of embriotoxicity, teratogenecity and mutability. However, industrially isolated DHQ is slightly soluble in water at room temperature and therefore has a limited bioavailability. This circumstance restricts the clinical use of dihydroquercrtin. In this study the lyophilization with different co-formers (vanillin, cinnamaldehyde, benzaldehyde, urea, and nicotinic acid) was used to improve the water-solubility of DHQ. The logarithmic correlation between fractal dimensions of solid structures and solubility of DHQ lyophilisats was established during the fractal analysis of photomicrographs by using of FDim software. The correlation coefficient was 0.89. The Relative standard deviation was not more than 1.75%. These results showed that fractal analysis can be used in the pharmaceutical industry as a promising method for rapid, automatic monitoring of quality control of pharmaceutical active ingredients without any substances loss.

Keywords: 
dihydroquercetin (taxifolin)
fractal analysis
lyophilized form
solubility in water

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