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TRITERPENOIDS OF CALENDULA OFFICINALIS FLOWERS

DOI: https://doi.org/10.29296/25877313-2018-06-01
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Issue: 
6
Year: 
2018

V.I. Ossipov Dr.Sc. (Biol.), Chief Research Scientist, Laboratory of Metabolomics, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow); Joint Russian-Finnish Biotechnology Laboratory (JBL) and Natural Compounds Research Group, Department of Chemistry, University of Turku (Turku, Finland) Е-mail: ossipov@utu.fi V.A. Bykov Dr.Sc.(Tech.), Academician of RAS, Chief Research Scientist, Laboratory of Metabolomics, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow); Joint Russian-Finnish Biotechnology Laboratory (JBL) and Natural Compounds Research Group, Department of Chemistry, University of Turku (Turku, Finland) F.M. Hazieva Ph.D. (Biol.), Head of Department of Agrobiology and Breeding, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) N.I. Sidel’nikov Dr.Sc.(Agricul.), Corresponding Member of RAS, Director, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)

The medicinal properties of Calendula officinalis plants are due to the content of various secondary metabolites. The most important among them are triterpenoids, which are mainly glycosides of oleanolic acid. The purpose of the work was to adapt the gas-liquid chromatography and ultra-performance liquid chromatography in combination with mass-spectrometric detection methods (GC-MS and UPLC-MS) to study the composition of triterpenoids in flow-ers of three varieties of Calendula officinalis: "Calta", "Golden Sea" and "Garden of Eden". As a result, there were found four calendulosides (H, G, F and E), two not identified oleanolic acid glycosides and aglycone β-amyrin, which is a precursor in the biosynthesis of oleanolic acid. Differences in the composition and total content of triterpenoids in the flowers of the studied varieties were not established
Keywords: 
Calendula officinalis
flowers
triterpenoids
GC-MS
UPLC-MS

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