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CONTENT OF CONTROL POINTS OF THE IMMUNITY SPD-1 AND SPD-L1 IN THE BLOOD PLASMA OF OVARIAN CANCER PATIENTS

DOI: https://doi.org/10.29296/25877313-2020-05-05
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Issue: 
5
Year: 
2020

D.O. Utkin Oncologist, Moscow City Oncological Hospital № 62 of the Department of Health of the City of Moscow (Istra) E-mail: utkindo@yandex.ru E.A. Korotkova Ph.D. (Biol.), Senior Research Scientist, N.N. Blokhin National Medical Research Center for Oncology of the Ministry of Health of Russia (Moscow) N.A. Petrikova Pathologist, Ryazan Regional Clinical Oncology Center (Ryazan) V.D. Ermilova Ph.D. (Med.), Leading Research Scientist, Department of Pathological Anatomy of Human Tumors, N.N. Blokhin National Medical Research Center for Oncology of the Ministry of Health of Russia (Moscow) M.M. Khulamkhanova Oncologist, N.N. Blokhin National Medical Research Center for Oncology of the Ministry of Health of Russia (Moscow) D.N. Kushlinsky Ph.D. (Med.), Senior Research Scientist, A.F. Tsyb Medical Radiological Scientific Center  branch of the Federal State Budgetary Institution National Medical Research Center for Radiology (Obninsk) N.Yu. Sokolov Ph.D. (Med.), N.N. Blokhin National Medical Research Center for Oncology of the Ministry of Health of Russia (Moscow) K.I. Zhordania Dr.Sc. (Med.),Professor, Department of Gynecology, N.N. Blokhin National Medical Research Center for Oncology of the Ministry of Health of Russia (Moscow) E.S. Gerstein Dr.Sc. (Biol.), Professor, Leading Research Scientist, N.N. Blokhin National Medical Research Center for Oncology of the Ministry of Health of Russia (Moscow)

Relevance. In recent years, close attention has been paid to the study of the expression of the PD-1 / PD-L1 signaling pathway in malignant tumors, including ovarian cancer (OC). The low effectiveness of the treatment of OC can be associated with various factors, including the mechanisms of the tumor escaping from the immune response through the PD-1 / PD-L1 immunity checkpoint system. Relatively recently, studies have appeared on the study of soluble forms of PD-1 and its ligands (sPD-1, sPD-L1 / 2) in the blood of cancer patients. These data are beginning to be actively used in an oncology clinic in the treatment of melanoma, renal cell carcinoma, non-small cell lung cancer. Purpose of the study. Analysis of the content of sPD-1 and sPD-L1 in the blood plasma of patients with OC, taking into account the main clinical and morphological characteristics of the disease. Material and methods. We examined 93 patients with OС, 22 with benign ovarian neoplasms, 10 with borderline ovarian tumors, and 35 with healthy women in the control group. In all, an ovarian tumor was detected for the first time and confirmed by histological examination. The concentra-tions of sPD-L1 and sPD-1 were determined in the blood plasma of patients and healthy women before the start of specific treatment using standard reagent kits for direct enzyme immunoassay Human PD-L1 Platinum ELISA and Human PD-1 ELISA kit (Affymetrix, eBioscience, USA) in accordance with the manufacturer's instructions. The reliability of the differences was evaluated using nonparametric tests (Mann-Whitney U-test, Kolmogorov-Smirnov type test). For all statistical tests, p values
Keywords: 
ovarian cancer
biomarkers
sPD-1
sPD-L1
blood plasma

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