Нажмите на эту строку чтобы перейти к Новостям сайта "Русский врач"

Перейти
на сайт
журнала
"Врач"
Перейти на сайт журнала "Медицинская сестра"
Перейти на сайт журнала "Фармация"
Перейти на сайт журнала "Молекулярная медицина"
Перейти на сайт журнала "Вопросы биологической, медицинской и фармацевтической химии"
Журнал включен в российские и международные библиотечные и реферативные базы данных

ВАК (Россия)
РИНЦ (Россия)
Эко-Вектор (Россия)

COMPONENT ANALYSIS OF THE ESSENTIAL OIL OF THE ABOVE GROUND PART OF DRACOCEPHALUM BOTRYOIDES STEVEN

DOI: https://doi.org/10.29296/25877313-2022-10-02
Download full text PDF
Issue: 
10
Year: 
2022

F.A. Vagabova
Ph.D. (Eng.), Senior Research Scientist, Laboratory of Phytochemistry and Medical Botany,
Mountain Botanical Garden, Dagestan Federal Research Center of RAS (Makhachkala, Russia)
Е-mail: fazina@mail.ru
A.M. Aliev
Head of Laboratory of Phytochemistry and Medical Botany,
Mountain Botanical Garden, Dagestan Federal Research Center of RAS (Makhachkala, Russia)
Е-mail: aslan4848@yahoo.com

The purpose of the study was to study the component composition of the essential oil of the aerial part of Dracocephalum botryoides Steven by chromatography-mass spectrometry to evaluate its use as a promising medicinal raw material. Material and methods. The raw materials for the study were collected in August 2013 during the flowering phase in the Dagestan natural population at an altitude of 2615 m above sea level (Dagestan, Russia). The yellow essential oil (0.31% of the air-dry flow) is obtained by hydrodistillation on a Clevenger apparatus for 4 hours. Results. In the course of the analyzes carried out on the method of chromato-mass spectrometry, 41 components were identified, of which 16 com-ponents (α-thuyene, thuya-2,4(10)-diene, sabinene, α-terpinene, p-cymene, γ-terpinene, β -thujone, linalool, α-muurolol, β-elemen, caryophyllene oxide, terpinen-4-ol, γ-elemen, trans-caryophyllene, β-elemenone, γ-muurolen) are the main compounds of D. botryoides essential oil. Three monoterpenes (α-thuyene, sabinene and p-cymene) occur in the maximum amount, which is 48.1% of the total amount of all identified components. Conclusions. For the first time, data are presented on the study of the composition of the essential oil of the aerial part of D. botryoides. Comparison of the results of the component composition of the essential oil of the studied sample with other species of the genus Dracocephalum revealed both similarity and difference in the composition of essential oils. The results obtained make it possible to characterize the essential oil of D. botryoides as a source of valuable components known for their biological activity, which is of great interest for further research.
Keywords: 
Dracocephalum botryoides Steven
essential oil
terpenoids
sesquiterpenoids
chromato-mass spectrometry

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Dracocephalum. The Plant List (2013). Версия 1.1. http://www.theplantlist.org.
  2. Aćimović M., Sikora V., Brdar-Jokanović M., et al. Draco-cephalum moldovica: cultivation, chemical composition and biological activity. Journal of Agronomy, Technology and Engineering Management. 2019; 2(1): 153–167.
  3. Aćimović M., Stanković J., Cvetković M., Todosijević M., Rat M. The chemical composition of the essential oil of Draco-cephalum moldavica L. from Vojvodina Province (Serbia). Biologica Nyssana. 2019; 10(1): 23–28. https://doi.org/ 10.5281/zenodo.3463994.
  4. Shanaida M., Pryshlyak A., Shanaida V. Gas chromatography mass spectrometric analysis of carboxylic acids in the herbs of two Dracocephalum L. species. PhOL–Pharmacology OnLine. 2021; 3: 15–20. http://pharmacologyonline.silae.it.
  5. Azimova Sh.S., Glushenkova A.I. Lipuds, lipophilic components and essential oil from plant sources. London. 2012; 810 с. https://doi.org/10.1007/978-0-85729-323-7.
  6. Mjadelec M.A., Domrachev D.V., Cheremushkina V.A. Issledovanie himicheskogo sostava jefirnyh masel nekotoryh vidov semejstva Lamiaceae L., kul'tiviruemyh v uslovijah Zapadnoj Sibiri. Himija rastitel'nogo syr'ja. 2012; 1: 111–117. https://cyberleninka.ru/article/n/is-sledovanie-himicheskogo-sostava-efirnyh-masel-nekotoryh-vidov-semeystva-lamiaceae-l-kultiviruemyh-v-usloviyah-zapadnoy-sibiri.
  7. Shavarda A.L., Budancev A.L. Soderzhanie i komponentnyj sostav jefirnogo masla Dracocephalum diversifolium (Lamiaceae). Rastitel'nye resursy. 2009; 45(2): 63–76.
  8. Shavarda A.L., Budancev A.L. Analiz jefirnogo masla Dracocephalum oblongifolium (Lamiaceae) s ispol'zovaniem polnoj dvumernoj hromatografii. Rastitel'nye resursy. 2013; 1: 107–117.
  9. Golparvar A.R., Hadipanah A., Heisari M.M., Khaliliazar R. Chemical constituents of essential oil of Dracocephalum moldavica L. and Dracocephalum kotschyi Boiss. from Iran. Acta Agriculturae Slovenica. 2016; 107(1): 25–31. https://doi.org/10.14720/Aas.2016.107.1.03.
  10. Melieva Sh.O., Bobakulov H.M., Abdullaeva N.S., Karimov A., Eshbakova K.A. Jefirnoe maslo i letuchie komponenty Dracocephalum diversifolium. Himija rastitel'nogo syr'ja. 2020; 2: 87–92. https://doi.org/10.14258/ Jcprm.2020026064.
  11. Zhang C.J., Li H.Y., Yun T., Fu H., Liu C.M. et al. Chemical composition, antimicrobial and antioxidant activities of the essential oil of Tibetan herbal medicine Dracocephalum heterophyllum Benth. Nat. Prod. Res. 2008; 22:1–11. https://doi.org/10.1080/14786410701619076.
  12. Zeng O., Jin H-Z., Qin J.-J., Hu X.-J, Yan L. et al. Chemical constituents of plants from the Genus Dracocephalum. Chemstry&Biodiversity. 2010; 7: 1911–1929. https://doi.org/ 10.1002/cbdv.200900188.
  13. Zhou Sh., Wei C., Zhang Ch., Han C., Kuchkarova N. et al. Chemical composition, phytotoxic, antimicrobial and insecticidal activity of the essential oils of Dracocephalum integrifolium. Toxins. 2019; 11(10): 598. https://doi:10.3390/toxins11100598.
  14. WHO. The World Flora Online. http://www.world-floraonline.org/taxon/wfo-0000945299#A.
  15. Murtazaliev R.A. Konspekt flory Dagestana. Otv. red. chl.-korr. RANR.V. Kamelin. Mahachkala: «Jepoha». 2009; 3: 304.
  16. Gosudarstvennaja farmakopeja Rossijskoj Federacii, 14 izd. Obshhie farmakopejnye stat'i: OFS.1.5.2.0001.15 Jefirnye masla, OFS.1.5.3.0010.15 Opredelenie soderzhanija jefirnogo masla v lekarstvennom rastitel'nom syr'e i lekarstvennyh rastitel'nyh preparatah. MZ RF. M. 2018.
  17. Majdouba S., Mokni E., Muradalievich A.A., Piras A., Porcedda S., et al. Effect of pressure variation on the ef-ficiency of supercritical fluid extraction of wild carrot (Daucus carota subsp. maritimus) extracts. Journal of Chro-matography B. 2019; 1125: 121713. https://doi.org/10.1016/ j.jchromb.2019.121713.
  18. Maham M., Akbari H., Delazar A. Chemical composition and antinociceptive effect of the essential oil of Dracocephalum moldavica L. Pharmaceutical sciences. 2013; 18(4): 187–192. http://pharm-sci.tbzmed.ac.ir.
  19. Sadhasivam S., Palanivel S., Ghosh S. Synergistic antimicrobial activity of Boswellia serrata Roxb. ex Colebr. (Burseraceae) essential oil with various azoles against pathogens associated with skin, scalp and nail infections. Letter in Applied Microbiology. 2016; 63(6): 495–501. https://doi.org/10.1111/lam.12683.
  20. Morshedi D., Aliakbari F., Tayaranian-Marvian A., Fassihi A., Pan-Montojo F., et al. Cuminaldehyde as the Major Component of Cuminumcyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity // Journal of Food Science. 2015; 80(10): H2336–H2345. https://doi.org/10.1111/1750-3841.13016.
  21. Hart P.H., Brand C., Carson C.F., Riley T.V., Prager R.H. et al. Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Inflammation Research. 2000; 49(11): 619–625. https://doi.org/10.1007/s000110050639.
  22. Banjerdpongchai R., Khaw-On P. Terpinen-4-ol Induces Autophagic and Apoptotic Cell Death in Human Leukemic HL-60 Cells. Asian Pacific Journal of Cancer Prevention. 2013; 14(12): 7537–7542. http://dx.doi.org/10.7314/ APJCP.2013.14.12.7537.
  23. Hac-Wydro K., Flasinski M., Broniatowski M., Soltys M. Studies on the Behavior of Eucalyptol and Terpinen-4-olNatural Food Additives and Ecological Pesticidesin Model Lipid Membranes. Langmuir. 2017; 33(27): 6916–6924. https://doi.org/10.1021/acs.langmuir.7b00774
  24. Nakayama K., Murata S., Ito H., Iwasaki K., Villareal M.O. et al. Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species. Oncology Letters. – 2017; 14(2): 2015–2024. https://doi.org/10.3892/ol.2017.6370.