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EVALUATION OF DOPAMINERGIC ACTIVITY OF BIOLOGICALLY ACTIVE SUBSTANCES OF VERBENA HERB (VERBENA OFFICINALIS L.)

DOI: https://doi.org/10.29296/25877313-2023-04-03
Issue: 
4
Year: 
2023

O.Yu. Kulyak
Ph.D (Pharm.), Research Scientist, Laboratory of Atomic-Molecular Bioregulation and Selection,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants;
Faculty of Fundamental Medicine, Lomonosov Moscow State University (Moscow, Russia)
E-mail: Kulyak-Olesya@mail.ru
G.V. Adamov
Ph.D (Pharm.), Senior Research Scientist, Laboratory of Atomic-Molecular Bioregulation and Selection,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
A.I. Radimich
Senior Research Scientist, Laboratory of Atomic-Molecular Bioregulation and Selection,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
I.A. Lupanova
Ph.D. (Biol.), Нead of the Center for Preclinical Studies,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
O.L. Saybel
Dr.Sc. (Pharm.), Head of the Center for Chemistry and Pharmaceutical Technology,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)

Relevance. The development of herbal medicines remains relevant today. Verbena officinalis L. has a spectrum of pharmacological activity, but our interest is manifested in its ability to treat amenorrhea and anovulation in hyperprolactinemia. The purpose of the work was to study the dopaminergic activity of the extract, fractions and dominant substances of the verbena officinalis herb. Materials and methods. The object of the study is the verbena officinalis herb, harvested experimentally in the field of the Botanical Garden of the Federal State Budgetary Scientific Institution VILAR in 2019. Results. The dopaminergic activity of fractions of different polarity of herb verbena officinalis was assessed. The most active absorb ethyl acetate fraction, which includes: verbenalin and verbascoside. Verbenalin has been found to have a dopaminergic effect. Dopaminergic activity of the total ex-tract, ethyl acetate fraction and inflammation verbenalin. Conclusions. It is expedient to develop drugs for the treatment of amenorrhea and anovulation based on a total extract standardized for verbenalin.
Keywords: 
verbena officinalis
verbenalin
verbascoside
specific enzyme test systems
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