Нажмите на эту строку чтобы перейти к Новостям сайта "Русский врач"

Перейти
на сайт
журнала
"Врач"
Перейти на сайт журнала "Медицинская сестра"
Перейти на сайт журнала "Фармация"
Перейти на сайт журнала "Молекулярная медицина"
Перейти на сайт журнала "Вопросы биологической, медицинской и фармацевтической химии"
Журнал включен в российские и международные библиотечные и реферативные базы данных

ВАК (Россия)
РИНЦ (Россия)
Эко-Вектор (Россия)

CHEMICAL COMPOSITION, BIOLOGICAL ACTIVITY AND PROSPECTS FOR MEDICAL USE FRUITS ZIZIPHUS JUJUBA

DOI: https://doi.org/10.29296/25877313-2023-08-01
Issue: 
8
Year: 
2023

E.B. Nikiforova
Ph.D. (Pharm.), Associate Professor, Head of Department of Pharmacy,
Kuban State Medical University (Krasnodar, Russia)
E-mail: corpus@ksma.ru
P.G. Mizina
Dr.Sc. (Pharm.)., Professor,
FSBSI All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
E-mail: vilarnii@mail.ru
A.I. Shevchenko
Ph.D. (Pharm.), Associate Professor of Department of Pharmacy,
Kuban State Medical University (Krasnodar, Russia)
A.G. Nechaeva
Assistent, Department of Pharmacy,
Kuban State Medical University (Krasnodar, Russia)
V.V. Burlakova
Student, Faculty of Pharmacy,
Kuban State Medical University (Krasnodar, Russia)
E.G. Nikiforova
Student, Pediatric Faculty,
Kuban State Medical University (Krasnodar, Russia)
Y.V. Asaturov
Post-graduate Student,
FSBSI All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)

The development of herbal medicines continues to be an extremely important area of scientific research. One of the sources of such can be the fruits of the present Ziziphus jujuba Mill., which are increasingly becoming the object of research in relation to their chemical composition and various types of pharmacological activity. In this regard, the aim of the study was to analyze the current state of research in the field of chemical composition, bio-logical activity and prospects for the medical use of MNs. The conducted information and analytical search shows that phenolic compounds, triterpene acids and polysaccharides of jujube fruits are of the greatest scientific interest and applied value for medical use.

Keywords: 
Ziziphus jujuba Mill.
unabi
chinese date
fruits
chemical composition
biological activity.

References: 
  1. Liu SJ., Lv YP., Tang ZS., et al. Ziziphus jujuba Mill., a plant used as medicinal food: a review of its phytochemistry, pharmacology, quality control and future research. Phytochem Reviews. 2021; 20: 507–541.
  2. Hossain M.A. Phytopharmacological review on the Omani medici-nal plant: Ziziphus jujube. Journal of King Saud University. Sci-ence. 2018; 31: 13531357.
  3. Lu Y., Tao BAO, J. MO., et al. Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit. Journal of Zhejiang University-SCIENCE. 2021; 22: 431449.
  4. Shi‐han Q., Fang Y., Shuai E., et al. Comprehensive characterization of multiple components of Ziziphus jujuba Mill using UHPLC‐Q‐Exactive Orbitrap Mass Spectrometers. Food Science & Nutrition. 2022; 10: 4270-4295.
  5. Guo Y., Ni Y. Kokot S., et al. Evaluation of chemical components and properties of the Jujube fruit using near infrared spectroscopy and chemometrics. Spectrochimica acta. Part A. Molecular and bi-omolecular spectroscopy. 2015; 153: 7986.
  6. Xue X., Zhao A., Wang Y., et al. Composition and content of phe-nolic acids and flavonoids among the different varieties, develop-ment stages, and tissues of Chinese Jujube (Ziziphus jujuba Mill.). PLoS One. 2021; 14: 1626.
  7. Панюшкина Е.С., Хохлов С.Ю., Мельников В.А. и др. Сравни-тельная оценка содержания биологически активных веществ в продуктах переработки плодов зизифуса. Сб. науч. трудов Государственного Никитского ботанического сада. 2019; 148: 209216 (Panjushkina E.S., Hohlov S.Ju., Mel'nikov V.A. i dr. Sravnitel'naja ocenka soderzhanija biologicheski aktiv-nyh vesh-hestv v produktah pererabotki plodov zizifusa. Sb. nauch. trudov Gosudarstvennogo Nikitskogo bota-nicheskogo sada. 2019; 148: 209216).
  8. Arslan M., Xiaobo Z., Shi J., et al. In situ prediction of phenolic compounds in puff dried Ziziphus jujuba Mill. using hand-held spectral analytical system. Food Chemistry. 2020; 30: 127361.
  9. Muhammad N., Luo Z., Yang M., et al. The Nutritional, Medicinal, and Drought-Resistance Properties of Ziziphus Mill. Make It an Important Candidate for Alleviating Food Insecurity in arid Regions  A Case of Pakistan. Horticulturae. 2022; 8: 114.
  10. Gao Q.H., Wu P.T., Liu J.R., et al. Physico-chemical properties and antioxidant capacity of different jujube (Ziziphus jujuba Mill.) culti-vars grown in loess plateau of China. Scientia Horticulturae. 2011; 130(1): 6772.
  11. Mahajan R., Chopda M. Phyto-Pharmacology of Ziziphus jujuba Mill.  A plant review. Pharmacognosy Reviews. 2009; №3: 320329.
  12. Ji X., Peng Q., Yuan Y., et al. Isolation, structures and bioactivities of the polysaccharides from jujube fruit (Ziziphus jujuba Mill.): A review. Food Chemistry. 2017; 15: 349357.
  13. Ji X., Zhang S., Jin X., et al. Systematic Comparison of Structural Characterization of Polysaccharides from Ziziphus Jujuba cv. Mu-zao. Molecules. 2023; 28(2): 562.
  14. Ji X., Zhang F., Zhang R., et al. An acidic polysaccharide from Ziziphus Jujuba cv. Muzao: Purification and structural characteriza-tion. Food Chemistry. 2019; 274: 494499.
  15. Yang Y., Qiu Z., Li L., et al. Structural characterization and antioxi-dant activities of one neutral polysaccharide and three acid polysac-charides from Ziziphus jujuba cv. Hamidazao: A comparison. Car-bohydrate Polymers. 2021; 261: 117879.
  16. Cai Y., Chen P., Wu C., et al. Sulfated modification and biological activities of polysaccharides derived from Zizyphus jujuba cv. Jin-changzao. International Journal of Biological Macromolecules. 2018; 120: 11491155.
  17. Abdurahman A., Momin A., Zhao L., et al. Bioactive, nutritional composition, heavy metal and pesticide residue of four Chinese ju-jube cultivars. Food Science and Biotechnology. 2018; 27: 323–331.
  18. Song J., Bi J., Chen Q., et al. Assessment of sugar content, fatty ac-ids, free amino acids, and volatile profiles in jujube fruits at differ-ent ripening stages. Food Chemistry. 2018; 280: 344-352.
  19. Tepe F.B., Ekinci R., Kadakal C., et al. A Review: The Physical, Nutritional, Bioactive Properties and Health Benefits of Jujube Fruit. Celal Bayar University Journal of Science. 2022; 18(1): 6775.
  20. Kou X.H., Chen Q., Li X.H., et al. Quantitative assessment of bio-active compounds and the antioxidant activity of 15 jujube cultivars. Food Chemistry. 2015; 173: 10371044.
  21. Song L.J., Zhang L, Xu L., et al. Optimized extraction of total triterpenoids from jujube (Ziziphus jujuba Mill.) and comprehen-sive analysis of triterpenic acids in different cultivars. Plants. 2020; (4): 412.
  22. Wojdyło A., Carbonell-Barrachina Á.A., Legua P., et al. Phenolic composition, ascorbic acid content, and antioxi‐ dant capacity of Spanish jujube (Ziziphus jujube Mill.) fruits. Food Chemistry. 2016; 201: 307314.
  23. Семкина О. А., Асатуров Ю.В., Борисенко Е.В. Перспективы применения лекарственных средств на основе плодов Ziziphus jujuba Mill. при лечении заболеваний желудочно-кишечного тракта. Вопросы биологической, медицинской и фармацевтиче-ской химии. 2022; 25(12): 1824 (Semkina O. A., Asaturov Ju.V., Borisenko E.V. Perspektivy primenenija lekarstvennyh sredstv na osnove plodov Ziziphus jujuba Mill. pri lechenii zabolevanij zheludochno-kishechno-go trakta. Voprosy biologicheskoj, medicinskoj i farmacev-ticheskoj himii. 2022; 25(12): 1824).
  24. Miklavčič Višnjevec A., Baruca Arbeiter A., Hladnik M., et al. An integrated characterization of jujube (Ziziphus jujuba Mill.) grown in the north Adriatic region. Food Technology and Biotechnology. 2019; 57(1): 1728.
  25. Hernández F., Noguera-Artiaga L., Burló F., et al. Physico-chemical, nutritional, and volatile composition and sensory profile of Spanish jujube (Ziziphus jujuba Mill.) fruits. Journal of the Sci-ence of Food and Agriculture. 2016; 96(8): 26822691.
  26. Барнаулов О.Д. Краткий обзор лекарственных свойств унаби Ziziphus jujube. Традиционная медицина. 2016; 2(45): 5061 (Barnaulov O.D. Kratkij obzor lekarstvennyh svojstv unabi Ziziphus jujube. Tradicionnaja medicina. 2016; 2(45): 5061).
  27. Ghobadi A., Amini-Behbahani F., Yousefi A. Medicinal and Nutri-tional Properties of Ziziphus jujuba Mill. in Traditional Persian Medicine and Modern Phytotherapy. Crescent Journal of Medical and Biological Sciences. 2019; 6(2): 146150.
  28. Xue Z., Feng W., Cao J., et al. Antioxidant activity and total phenol-ic contents in peel and pulp of Chinese jujube (Ziziphus jujuba Mill.) fruits. Journal of Food Biochemistry. 2009; 33(5): 613–629.
  29. Zhang H., Jiang L., Ye S., et al. Systematic evaluation of antioxi-dant capacities of the ethanolic extract of different tissues of jujube (Ziziphus jujuba Mill.) from China. Food Chem. Toxicology. 2010; 48(6): 14611466.
  30. Gao Q.H., Wu C., Yu J.G., et al. Textural Characteristic, Antioxi-dant Activity, Sugar, Organic Acid, and Phenolic Profiles of 10 Promising Jujube (Ziziphus jujuba Mill.) Selections. Journal of food science. 2012; 77: 12181243.
  31. Chen J., Lam C.T., Li Z., et al. Extract of Ziziphus jujuba Fruit (Ju-jube) Stimulates Expression of Enzymes Responsible for Heme Re-cycle via Anti-oxidant Response Element in Cultured Murine Mac-rophages. Phytotherapy Research. 2016; 30(2): 267271.
  32. Ji X., Hou C., Yan Y., et al. Comparison of structural characteriza-tion and antioxidant activity of polysaccharides from jujube (Ziziphus jujuba Mill.) fruit. International journal of biological mac-romolecules. 2020; 149: 10081018.
  33. Zhang L., Liu X., Wang Y., et al. In vitro antioxidative and immuno-logical activities of polysaccharides from Zizyphus Jujuba cv. Mu-zao. International Journal of Biological Macromolecules. 2016; 95: 11191125.
  34. Yang Y., Qiu Z., Li L., et al. Structural characterization and antioxi-dant activities of one neutral polysaccharide and three acid polysac-charides from Ziziphus jujuba cv. Hamidazao: A comparison. Car-bohydrate Polymers. 2021; 261: 117879.
  35. Zare-Zardini H., Tolueinia B., Hashemi A., et al. Antioxidant and Cholinesterase Inhibitory Activity of a New Peptide from Ziziphus jujuba Fruits. American journal of Alzheimer's disease and other dementias. 2013; 28: 702711.
  36. Chen J., Du C., Lam K., et al. The Standardized Extract of Ziziphus jujuba Fruit (Jujube) Regulates Pro-inflammatory Cytokine Expres-sion in Cultured Murine Macrophages: Suppression of Lipopoly-saccharide-stimulated NF-κB Activity. Phytotherapy Research. 2014; 28: 15271559.
  37. Yu L., Jiang B.P., Luo D., et al. Bioactive components in the fruits of Ziziphus jujuba Mill. against the inflammatory irritant action of Euphorbia plants. Phytomedicine: international journal of phyto-therapy and phytopharmacology. 2012; 19: 239283.
  38. Mesaik A., Poh H., Bin O., et al. In Vivo Anti-Inflammatory, Anti-Bacterial and Anti-Diarrhoeal Activity of Ziziphus Jujuba Fruit Ex-tract. Open Access Macedonian Journal of Medical Sciences. 2018; 6: 757766.
  39. Zhou H.C., Guo C.‐A., Yu W.-W., et al. Zizyphus jujuba cv. Muzao polysaccharides enhance intestinal barrier function and improve the survival of septic mice. Journal of Food Biochemistry. 2021; 45: 13722.
  40. Zou M., Chen Y., Sun-Waterhouse D., et al. Immunomodulatory acidic polysaccharides from Zizyphus jujuba cv. Huizao: Insights into their chemical characteristics and modes of action. Food Chem-istry. 2018; 258: 3542.
  41. Li J., Shan L., Liu Y., et al. Screening of a Functional Polysaccha-ride from Zizyphus Jujuba cv. Jinsixiaozao and its Property. Inter-national journal of biological macromolecules. 2011; 49: 255264.
  42. Miao W., Sheng L., Yang T., et al. The impact of flavonoids-rich Ziziphus jujuba Mill. extract on Staphylococcus aureus biofilm formation. BMC Complementary Medicine and Therapies. 2020; 20: 187.
  43. Xu D., Xiao J., Jiang D., et al. Inhibitory effects of a water-soluble jujube polysaccharide against biofilm-forming oral pathogenic bac-teria. International Journal of Biological Macromolecules. 2022; 208: 10461062.
  44. Daneshmand F., Zardini H., Tolueinia B., et al. Crude Extract from Ziziphus Jujuba Fruits, a Weapon against Pediatric Infectious Dis-ease. Iranian journal of pediatric hematology and oncology. 2013; 3: 216237.
  45. Fazil M., Nikhat S. Therapeutic and palliative role of a Unani herbal decoction in COVID-19 and similar respiratory viral illnesses: Phy-tochemical & pharmacological perspective. Journal of Ethnophar-macology. 2022; 297: 115526.
  46. Tedyanto C.P., Wihanto L., Hendrata A.P. Hepatoprotective Effect of Dried Red Jujube Fruit Extract Against Acetaminophen-Induced Acute Hepatotoxicity. Cureus. 2023; 15(1): 33272.
  47. Hong S., Kim Y., Sung J., et al. Jujube (Ziziphus jujuba Mill.) Pro-tects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation. Evid Based Complement Alternat Medicine. 2020; 2020: 6684331.
  48. Rajopadhye A., Upadhye A.S. Estimation of Bioactive Compound, Maslinic Acid by HPTLC, and Evaluation of Hepatoprotective Ac-tivity on Fruit Pulp of Ziziphus jujuba Mill. Cultivars in India. Evid Based Complement Alternat Medicine. 2016; 2016: 4758734.
  49. Yue Y., Wu S., Zhang H., et al. Characterization and hepatoprotec-tive effect of polysaccharides from Ziziphus jujuba Mill. var. spi-nosa (Bunge) Hu ex H. F. Chou sarcocarp. Food and Chemical Toxicology. 2014; 74(7): 684.
  50. Tahergorabi Z., Abedini M., Moodi M., et al. Ziziphus jujuba: A red fruit with promising anticancer activities. Pharmacognosy re-views. 2015; 9: 99106.
  51. Shin M., Lee B.M., Kim O., et al. Triterpenoids from Ziziphus ju-juba induce apoptotic cell death in human cancer cells through mito-chondrial reactive oxygen species production. Food Function. 2018; 9(7): 38953905.
  52. Ruan J., Li H., Lu M., et al. Bioactive triterpenes of jujube in the prevention of colorectal cancer and their molecular mechanism re-search. Phytomedicine. 2023; 110: 154639.
  53. Hung C.F., Hsu B.Y., Chang S.C., et al. Antiproliferation of mela-noma cells by polysaccharide isolated from Zizyphus jujube. Nutri-tion. 2012; 28(1): 98105.