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THE HYDROXAMIC REACTION IN THE ANALYSIS OF 2-ACETOXYBENZOIC ACID AND OF N-(4-HYDROXYPHENYL) ACETAMIDE
DOI: https://doi.org/10.29296/25877313-2018-11-05
Issue:
11
Year:
2018
The study of the conditions of hydroxamate reaction depending on the pH for the acid 2 –acetoxybenzoic and N-(4-hydroxyphenyl) acetamide, simultaneously included in the composition of the tablets «Askofen-P» and «Citramon-P». Materials and methods. We used pharmaceutical substances of acetylsalicylic acid and paracetamol, which meet the requirements of the corre-sponding pharmacopoeial articles. When performing the experiments, solvents and reagents with the “pure for analysis” qualification were used. A proce-dure for analyzing acetylsalicylic acid and three variants of the method for analyzing paracetamol (at different pH) are presented. Results and discussion. As a result of the study was found that for 2-acetoxybenzoic acid we observed copper hydroxamate in the form of green solution, later a green sediment fell out, iron hydroxamate - in the form of red solution. In the case of decreasing of pH range till 4 the visible effect wasn't distinguished from the previous colours. For N-(4-hydroxyphenyl) acetamide (paracetamol) we observed the copper hydroxamate in the form of green sediment moving to a bright blue solution, with the solution of iron (III) chloride - an orange-red solution. Conclusions. The hydroxamic reaction for 2-acetoxybenzoic acid with copper and iron (III) salts passes in slightly basic, neutral and slightly acidic medium. The forming of copper hydroxamate in the case of N-4-hydroxyphenyl acetamide passes in the range of рН from 7 to рН=5. The forming of iron (III) hydroxamate passes in the range of рН from 5 to рН=2.
Keywords:
hydroxamic test
acetylsalicylic acid
paracetamol
References:
- Ispol'zovanie raznyh kontsentratsij rastvora gidroksida natrija ne vlijaet na vidimyj effekt gidroksamovoj proby dlja kisloty 2-atsetoksibenzojnoj s soljami medi i zheleza (III). Reaktsija idet kak v slaboschelochnoj, nejtral'noj, tak i v slabokisloj srede.
- Obrazovanie gidroksamata medi v sluchae N-(4-gidroksifenil) atsetamida proishodit v intervale ot rN=7 do rN=5, obrazovanie gidroksamata zheleza (III) - v intervale ot rN=5 do rN=2.
- Korenman I.M. Fotometricheskij analiz. Metody opre-delenija organicheskih soedinenij. Izd. 2-e, pererab. i dop. M.: Himija. 1975. S. 269–272.
- Arzamastsev A.P., Dorofeev V.L., Konovalov A.A., Kochin V.Ju., Lebedeva N.I., Titov I.V. Ftorhinolony i tsefalo-sporiny: prakticheskoe rukovodstvo // Ekspress analiz s tsel'ju vyjavlenija fal'sifitsirovannyh lekarstvennyh sredstv. M.: Izdatel'skij dom «Russkij vrach». 2003. S. 41.
- Gosudarstvennaja farmakopeja Rossijskoj Federatsii. M.: Izd-vo «Nauchnyj tsentr ekspertizy sredstv meditsinskogo primenenija». 2008. FS 42-0220-07 Atsetilsalitsilovaja kislota.
- Gosudarstvennaja farmakopeja Rossijskoj Federa-tsii. M.: Izd-vo «Nauchnyj tsentr ekspertizy sredstv meditsinskogo primenenija», 2008; FS 42-0268-07 Paratsetamol.