DOI: https://doi.org/10.29296/25877313-2019-10-07

V.P. Deryagina Ph.D. (Biol.), N.N. Blokhin National Medical Research Center of Oncology Russian Federation Ministry of Health (Moscow) E-mail: derygina@inbox.ru N.I. Ryzhova Ph.D. (Biol.), N.N. Blokhin National Medical Research Center of Oncology Russian Federation Ministry of Health (Moscow) K.I. Kirsanov Ph.D. (Biol.), N.N. Blokhin National Medical Research Center of Oncology Russian Federation Ministry of Health; Peoples' Friendship University of Russia (Moscow) L.A. Savluchinskaya Ph.D. (Biol.), N.N. Blokhin National Medical Research Center of Oncology Russian Federation Ministry of Health (Moscow) N.A. Golubkina Dr.Sc. (Agric.), Federal Scientific Center of Vegetable Production (Moskow Region, Odintsovo District, VNIISSOK)

Aim. The aim of the study was to investigate the ability of water-ethanol extracts of tarragon Artemisia dracunculus L. and black parsnip Pasti-naca sativa L. to increase the body's antitumor resistance to transplanted tumor cells and have an antitumor effect on the growth and metastasis tu-mors in mice. Material and Methods. In the study mice with metastatic Lewis carcinoma, were used. The inhibitory effect of tarragon Artemisia dracunculus L., “Izumrud” cultivar and parsnip Pastinaca sativa L. was evaluated by inhibition of tumor growth and reduction of metastases in mice lung. Results. A comprehensive study of the chemical composition of tarragon Artimisia dracunculus L. and parsnip Pastinaca sativa L. has identified a wide range of biologically active substances capable to participate in anti-carcinogenic protection. It was shown that water-alcohol extract of tarragon Artemisia dracunculus L. did not significantly affect the growth of tumors and potent metastasizing in mice with carcinoma of Lewis. Water-alcohol ex-tract of parsnip Pastinaca sativa L. (3.2%) demonstrated a significant inhibition of tumor growth and had a pronounced anti-metastatic effect. Conclusion. The results indicate the prospect of further study of the anticancer properties of black parsnip and its biologically active com-pounds.

tarragon Artimisia dracunculus L.
fermented black parsnip
Lewis carcinoma
tumor growth inhibition

  1. Belickij G.A., Kirsanov K.I., Lesovaja E.A., Jakubovskaja M.G. Prirodnye ingibitory kancerogeneza. Molekuljarnyj kancerogenez. M.: AVS-press, 2016.
  2. S. 158−177.
  3. Kaur V., Kumar M., Kumar A., Kaur K. Pharmacotherapeutic potencial of phytochemicals: Implications in cancer chemoprevention and future perspectives // Biomedicine & Pharmacotherapy. 2018; 97: 564−586. PMID: 29101800; doi:10.1016/j.biopha.2017.10.124.
  4. Derjagina V.P., Reutov V.P. Modulirovanie obrazovanija aktivnyh form azota ingredientami rastitel'nyh produktov pri ingibirovanii kancerogeneza // Uspehi molekuljarnoj onkologii. 2019. 6(1):18−36.
  5. Koul B., Taak P., Kumar A., Khatri T., Sanyal I. The Artemisia Genus: A Review on Traditional Uses, Phytochemical Constituents, Pharmacological Properties and Germplasm Conservation // J. Glycomics Lipidomics. 2017; 7: 142. doi: 10.4172/2153-0637.10001425.
  6. Logvinenko L.A., Plugatar' Ju.V., Kancaeva U.I., Golubkina N.A, Molchanova A.V., Koval'skij Ju.G. Pishhevaja dobavka iz polyni jestragonnoj sorta «Izumrud». Patent RF 2689711 ot 14.08. 2018.
  7. Lai H.C. Development of artemisinin compounds for cancer treatment // Invest. New Drugs. 2013; 31(1): 230−246.
  8. Mumivand H., Babalar M., Tabrizi L., Craker L.E., Shokrpour M., Hadian J. Antioxidant properties and principal phenolic phytochemicals in Iranian tarragon (Artemisia dracunculus L.) аccessions // Hotic. Environ. Biotechnol. 2017; 58:414−422. https://doi.org/10.1007/s13580-017-0121-5.
  9. Hong L., Ying S.H. Ethanol extract and isolated constituents from Artemisia dracunculus inhibit esophageal squamous cell carcinoma and induce apoptotic cell death // Drug Res (Stuttg). 2015; 65(2):101−106. doi: 10.1055/s-0034-1372647.
  10. Ibrahem N.M. Extraction and characterization of Iraqi Artemisia dracunculus dried aerial parts extract though HPLC and GC-MS analysis with evaluation of its anti-tumor activity against 7,12-dimethylbenze(a)anthracene induced skin cancer in mice // Int. J. Pharm. Sci. 2017; 9(5):34−42.
  11. Smith R.L., Adams T.B., Doull J. et al. Safety assessment of allylalkoxybenzene derivatives used as flavouring substances – methyl eugenol and estragole // Food and Chem. Toxicol. 2002; 40:851−870. PMID: 12065208.
  12. Golubkina N.A., Kekina E.G., Nadezhkin S.M. Priprava funkcional'nogo naznachenija s povyshennym soderzhaniem biologicheski aktivnyh veshhestv. Patent RF №20151028694A 13. 03. 2015.
  13. Rayman M.P. Selenium in cancer prevention: a review of the evidence and mechanism of action // Proc. Nutr. Soc. 2005; 64(4): 527−542. PMID: 16313696.
  14. Golubkina N.A., Kekina E.G., Molchanova A.V. Antoshkina M.S., Nadezhkin S.M., Soldatenko A.V. Antioksidanty rastenij i metody ih opredelenija. M.: Izd-vo FGBNU FNCO. 2018. 66 s.
  15. Ryu J H, Kang D. Physicochemical Properties, Biological Activity, Health Benefits, and General Limitations of Aged Black Garlic: A Review // Molecules. 2017; 22 (6), 919. doi:10.3390/molecules22060919 PMID: 28587168.
  16. Purup S., Larsen E., Christensen L.P. Differential Effects of Falcarinol and Related Aliphatic C17-Polyacetylenes on Intestinal Cell Proliferation // J. Agric Food Chem. 2009; 57(18): 8290–6. doi: 10.1021/jf901503a.
  17. European Commission Scientific Committee on Food. Opinion of the Scientific Committee on Food on Estragole (1-Allyl-4-methoxybenzene). SCF/CS/FLAV/FLAVOUR/6 ADD2FINAL. 2001. http://ec.europa.eu/food/fs/sc/scf/out104 en.pdf.
  18. Antoshina E.E., Gor'kova T.G., Derjagina V.P., Ryzhova N.I. Ingibirujushhee dejstvie fenol'nyh kislot i raznyh form mikrovodorosli spiruliny na rost karcinomy Jerliha u myshej // Vestnik RONC im. N.N. Blohina RAMN. 2009; 20(4): 26−31.
  19. Melough M.M., Cho E., Chun O.K. Furocoumarins: A review of biochemical activities, dietary sources and intake, and potential health risks // Food and Chemical Toxicology. 2018. DOI: 10.1016/j.fct.2018.01.030.
  20. Xia W.; Gooden D.; Liu L., Zhao S. Photo-Activated Psoralen Binds the ErbB2 Catalytic Kinase Domain, Blocking ErbB2 Sig¬naling and Triggering Tumor Cell Apoptosis. 2014; PLoS ONE. 9(2): e88983. doi:10.1371/journal.pone.0088983.PMC3925176. PMID24551203.