EFFECT OF WATER-ETHANOL EXTRACTS OF TARRAGON (ARTIMISIA DRACUNCULUS L.) AND FERMENTED BLACK PARSNIP (PASTINACA SATIVA L.) ON GROWTH AND METASTASIS OF TRANSPLANTED CARCINOMA OF LEWIS IN MICE

DOI: https://doi.org/10.29296/25877313-2019-10-07
Issue: 
10
Year: 
2019

V.P. Deryagina Ph.D. (Biol.), N.N. Blokhin National Medical Research Center of Oncology Russian Federation Ministry of Health (Moscow) E-mail: derygina@inbox.ru N.I. Ryzhova Ph.D. (Biol.), N.N. Blokhin National Medical Research Center of Oncology Russian Federation Ministry of Health (Moscow) K.I. Kirsanov Ph.D. (Biol.), N.N. Blokhin National Medical Research Center of Oncology Russian Federation Ministry of Health; Peoples' Friendship University of Russia (Moscow) L.A. Savluchinskaya Ph.D. (Biol.), N.N. Blokhin National Medical Research Center of Oncology Russian Federation Ministry of Health (Moscow) N.A. Golubkina Dr.Sc. (Agric.), Federal Scientific Center of Vegetable Production (Moskow Region, Odintsovo District, VNIISSOK)

Aim. The aim of the study was to investigate the ability of water-ethanol extracts of tarragon Artemisia dracunculus L. and black parsnip Pasti-naca sativa L. to increase the body's antitumor resistance to transplanted tumor cells and have an antitumor effect on the growth and metastasis tu-mors in mice. Material and Methods. In the study mice with metastatic Lewis carcinoma, were used. The inhibitory effect of tarragon Artemisia dracunculus L., “Izumrud” cultivar and parsnip Pastinaca sativa L. was evaluated by inhibition of tumor growth and reduction of metastases in mice lung. Results. A comprehensive study of the chemical composition of tarragon Artimisia dracunculus L. and parsnip Pastinaca sativa L. has identified a wide range of biologically active substances capable to participate in anti-carcinogenic protection. It was shown that water-alcohol extract of tarragon Artemisia dracunculus L. did not significantly affect the growth of tumors and potent metastasizing in mice with carcinoma of Lewis. Water-alcohol ex-tract of parsnip Pastinaca sativa L. (3.2%) demonstrated a significant inhibition of tumor growth and had a pronounced anti-metastatic effect. Conclusion. The results indicate the prospect of further study of the anticancer properties of black parsnip and its biologically active com-pounds.

Keywords: 
tarragon Artimisia dracunculus L.
fermented black parsnip
Lewis carcinoma
tumor growth inhibition
metastasis

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