АНАЛИЗ МЕХАНИЗМА ДЕЙСТВИЯ ЖАСМОНАТОВ МЕТОДАМИ ВЫЧИСЛИТЕЛЬНОЙ ХИМИИ

DOI: https://doi.org/10.29296/25877313-2018-04-05
Номер журнала: 
4
Год издания: 
2018

Г.Ф. Куракин студент, лечебный факультет, ФГБОУ ВО Тверской ГМУ Минздрава России E-mail: phyzyk@mail.ru Н.П. Лопина к.х.н., доцент, кафедра химии, ФГБОУ ВО Тверской ГМУ Минздрава России Г.Е. Бордина к.б.н., доцент, кафедра химии, ФГБОУ ВО Тверской ГМУ Минздрава России

Проанализирован возможный механизм действия жасмонатов на организм человека методами предсказания мишени, докинга и фармакофорных наложений. Не обнаружено значимого фармакофорного сходства у жасмонатов с простагландинами, выявлено сходство с нестероидными противовоспалительными средствами.

Ключевые слова: 
жасмонаты
хемоинформатика
вычислительная химия
механизм действия
простагландины
НПВС
рецептор PPARγ

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