THE DISEASES OF THE ORAL CAVITY: TREATMENT OPTIONS AND PROSPECTS FOR THE CREATION OF EFFECTIVE DRUGS

DOI: https://doi.org/10.29296/25877313-2018-03-02
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Issue: 
3
Year: 
2018

D.O. Shatalov Ph.D. (Pharm.), Аssociate Professor, Department of Biomedical and Pharmaceuticals Technologies, Moscow Technological University; Deputy General Director, CJSC «Institute of pharmaceutical technologies» (Moscow) E-mail: shat-05@mail.ru S.А. Kedik, Dr.Sc. (Eng.), Professor, Head of Department of Biomedical and Pharmaceuticals Technologies, Moscow Technological University; General Director, CJSC «Institute of pharmaceutical technologies» (Moscow) A.V. Aydakova Student, Moscow Technological University E.A. Voroshilova Student, Moscow Technological University E.N. Mikhailenko Student, Moscow Technological University S.V. Beliakov Post-graduate Student, Department of Biomedical and Pharmaceuticals Technologies, Moscow Technological University M.M. Fedorova Student, Moscow Technological University

The dental diseases are called an extensive group of diseases occurring in the oral cavity, namely in the teeth and gums. The diseases of the oral cavity greatly complicate daily life and are a stressful factor for the majority of the population. The classification and clinical picture of the course of each type of the disease – stomatitis, gingivitis and periodontitis, risk factors and necessary prevention are presented. The probable schemes of treatment of the diseases of the oral cavity, as well as the types of medicines used for this are indicated. The antimicrobial substances used as active substances in medications are considered, their classification according to the structure and mechanism of action is given, the main indications for their application are described. The problems of application of these substances caused by the resistance of pathogenic microflora to the main classes of the biocides are discussed. Guanidinecontaining cationic polyelectrolytes with different structures affecting their features. Comparative information on the range of antimicrobial action of representatives of this class based on the results of studies conducted in different periods of time is presented. The analysis of the literature data demonstrated that branched oligohexamethyleneguanidine hydrochloride is a promising compound for the development of pharmaceutical substance. The data of studies of the toxicity of polyguanidines, as well as the results of studying the minimum inhibitory concentration of the substances of poly- and oligohexamethyleneguanidine hydrochloride and the available analogues are given. On the basis of the data obtained, it was concluded that, the previously branched oligohexamethylene guanidine hydrochloride should be used as a pharmaceutical substance.

Keywords: 
diseases of the oral cavity
synthetic cationic polymers
branched oligohexamethyleneguanidine hydrochloride

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