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THE DISEASES OF THE ORAL CAVITY: TREATMENT OPTIONS AND PROSPECTS FOR THE CREATION OF EFFECTIVE DRUGS
DOI: https://doi.org/10.29296/25877313-2018-03-02
Issue:
3
Year:
2018
The dental diseases are called an extensive group of diseases occurring in the oral cavity, namely in the teeth and gums. The diseases of the oral cavity greatly complicate daily life and are a stressful factor for the majority of the population. The classification and clinical picture of the course of each type of the disease – stomatitis, gingivitis and periodontitis, risk factors and necessary prevention are presented. The probable schemes of treatment of the diseases of the oral cavity, as well as the types of medicines used for this are indicated. The antimicrobial substances used as active substances in medications are considered, their classification according to the structure and mechanism of action is given, the main indications for their application are described. The problems of application of these substances caused by the resistance of pathogenic microflora to the main classes of the biocides are discussed. Guanidinecontaining cationic polyelectrolytes with different structures affecting their features. Comparative information on the range of antimicrobial action of representatives of this class based on the results of studies conducted in different periods of time is presented. The analysis of the literature data demonstrated that branched oligohexamethyleneguanidine hydrochloride is a promising compound for the development of pharmaceutical substance. The data of studies of the toxicity of polyguanidines, as well as the results of studying the minimum inhibitory concentration of the substances of poly- and oligohexamethyleneguanidine hydrochloride and the available analogues are given. On the basis of the data obtained, it was concluded that, the previously branched oligohexamethylene guanidine hydrochloride should be used as a pharmaceutical substance.
Keywords:
diseases of the oral cavity
synthetic cationic polymers
branched oligohexamethyleneguanidine hydrochloride
References:
- Pobozh'eva L.V., Kopetskij I.S. Rol' bioplenki v patogeneze vospalitel'nyh zabolevanij polosti rta i sposoby ee ustranenija // Lechebnoe delo. 2012. № 2. S. 9−13.
- Gileva O.S., Smirnova E.N., Pozdnjakova A.A., Pozdeeva O.V.,Libik T.V., Satjukova L.Ja., Haljavina I.N., Gorodilova E.A.Shilova T.Ju., Gibadullina N.V., Sadilova V.A., Nazukin E.D. Struktura, faktory riska i klinicheskie osobennosti zabolevanij slizistoj obolochki polosti rta (po dannym lechebno-konsul'tativnogo priema) // Permskij meditsinskij zhurnal. 2012. T. 29. № 6. S. 18−24.
- Marcenes W., Kassebaum N.J., Bernabé E., Flaxman A., Naghavi M., Lopez A., Murray C.J.L. Global Burden of Oral Conditions in 1990−2010: A Systematic Analysis // Journal of Dental Research. 2013. V. 92. № 7. R. 592−597.
- Zarco M.F., Vess T.J., Ginsburg G.S. The oral microbiome in health and disease and the potential impact on personalized dental medicine // Oral Diseases. 2012. № 18. R. 109–120.
- Shinkevich V.I., Udal'tsova K.A., Pisarenko E.A., Kolomiets S.V., Hmil' T.A. Simptomaticheskij gipertroficheskij gingivit pri hronicheskom parodontite: klinicheskij sluchaj i obzor literatury // Georgian medical news. 2015. № 12. R. 52−57.
- Cherkasov S.M. Analiz rasprostranennosti zabolevanij zubocheljustnoj sistemy, formirujuschih spros na stomatologicheskie uslugi // Fundamental'nye issledovanija. 2014. № 2. S. 186−189.
- Usova N.F. Vospalitel'nye zabolevanija parodonta: patogenez, printsipy kompleksnogo lechenija // Sibirskij meditsinskij zhurnal. 2013. № 1. S. 141−144.
- Gritsenko P.I., Petruk N.S., Samoylenko A.V., Tverdokhleb I.V. Cellular composition and ultrastructure of periapical granulation tissue in primary and secondary chronic periodontitis // Morphologia. 2014. V. 8, № 2. R. 53−57.
- Badashkeev M.V., Kljushnikov O.V., Kljushnikova M.O., Kljushnikova O.N. Rol' mikrobnogo faktora v etiologii vospalitel'nyh zabolevanij parodontat // Voprosy. Gipotezy. Otvety: nauka XXI v. Kollektivnaja monografija. 2013. № 6. S. 306.
- Vyshkovskij G.L. Registr lekarstvennyh sredstv Rossii RLS Entsiklopedija lekarstv. Vyp. 24. M.: RLS-MEDIA. 2016. 1296 s.
- Huang S., Li Z., He T., Bo C., Chang J., Li L., He Y., Jiquan L., Charbonneau D., Li R., Xub J. Microbiota-based Signature of Gingivitis Treatments: A Randomized Study // Scientific Reports. 2016. № 6. R. 67−78.
- Aspalli S., Shetty S., Devarathnamma M., Nagappa G., Archana D., Parab P. Evaluation of antiplaque and antigingivitis effect of herbal mouthwash in treatment of plaque induced gingivitis: A randomized, clinical trial // Indian Society of Periodontology. 2014. V. 18. № 1. R. 98−104.
- Gazhva S.I., Voronina A.I., Kul'kova D.A. Medikamentoznye shemy konservativnogo lechenija hronicheskih form parodontitov // Fundamental'nye issledovanija. 2013. № 5. S. 55−57.
- Novototskih A.A., Shatalov D.O., Kedik S.A., Zhavoronok E.S., Panov A.V., Ivanov I.S., Ajdakova A.V., Birjulin S.I., Kovalenko A.V., Mihajlenko E.N. Podhody k razrabotke gotovoj lekarstvennoj formy- stomatologicheskogo gelja dlja lechenija zabolevanij polosti rta (obzor) // Biofarmatsevticheskij zhurnal. 2016. T. 8. № 5. S. 3−8.
- Kedik S.A., Shatalov D.O., Beksaev S.G., Sedishev I.P., Zhavoronok E.S., Suslov V.V., Panov A.V. Razrabotka i validatsija metoda kontrolja monomernoj primesi gidrohlorida guanidina v farmatsevticheskoj substantsii «razvetvlennyj gidrohlorid oligogeksametilenguanidina» // Vestnik MITHT. 2014. T. 9. № 2. S. 32−36.
- Kedik S.A., Shatalov D.O., Ajdakova A.V. i dr. Otchet o prikladnyh nauchnyh issledovanijah i eksperimental'nyh razrabotkah. M. 2016. 185 s.
- Shatalov D.O., Kedik S.A., Zhavoronok E.S., Ajdakova A.V., Ivanov I.S., Evseeva A.S., Beljakov S.V., Birjulin S.I., Kovalenko A.V., Mihajlenko E.N. Opyt i perspektivy razvi-tija ispol'zovanija sinteticheskih antimikrobnyh veschestv // VSE MATERIALY. Entsiklopedicheskij spravochnik. 2016. № 8. S. 14−22.
- Ha K.A. Razrabotka tehnologii poluchenija substantsii gidrosuktsinata oligogeksametilenguanidina i glaznyh kapel' na ee osnove: Avtoref. diss. … kand. farm. nauk. M. 2012.
- Bagaeva V.V., Popova V.M., Pashkova G.S., Isadzhanjan K.E., Nikitin V.V., Zhilenkov E.L. Izuchenie effektivnosti i bezopasnosti primenenija antimikrobnyh sredstv // Issledovanija i praktika v meditsine. 2015. T. 2. № 3. S. 35−42.