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THE STUDY OF QUALITY INDICATORS OF PHARMACOPOEIA AND TECHNOLOGICAL PARAMETERS OF HERB CATNIP (NEPETA CATARIA L.)

DOI: https://doi.org/10.29296/25877313-2018-04-04
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Issue: 
4
Year: 
2018

Nguyen Thi Hai Yen Post-graduate Student, Department of Pharmaceutical Chemistry, Saint-Petersburg State Chemical-Pharmaceutical Academy E-mail: nguyenhaiyen20190@gmail.com I.I. Terninko Dr.Sc. (Pharm.), Associate Professor, Department of Pharmaceutical Chemistry, Head of the test Laboratory (Center for quality control of pharmaceutical products), Saint-Petersburg State Chemical-Pharmaceutical Academy E-mail: inatern@gmail.com

Introduction: Nepetacataria L. commonly known as Catnip, is herbaceous plant of Lamiaceae Family. Nepetacataria L. has been listed in the French pharmacopoeia 10th, the homoeopathic pharmacopoeia of the United States, the Chinese Pharmacopoeia of version 2015. It is distributed all round the world and used as drugs in traditional medicine. Moreover, in 2017 Fan J. et al. found that extract from Nepetacataria L. had significant anticancer effects. So Nepeta cataria L. is a promising plant medicine for research. Aim of the study: Study quality indicators of pharmacopoeia and technological parameters of Nepetacataria L. Materials and methods: Plants of Nepeta cataria L. were cultivated at the Saint Petersburg State Chemical-Pharmaceutical Academy’s Arboretum. For determination of quality indicators of pharmacopoeia, the guidelines established by the State Pharmacopoeia of the Russian Federation, 13th edition were employed and technological parameters were done according to Zhaparkulov K.A. (2016), Chueshov V.I. et. al. (2002) principles. Statistic processing of results was done using Microsoft Excel 2010 program. Results and discussion: The quality indicators of pharmacopoeia (loss on drying − 8,80±0,08%; total ash − 10,40±0,36%; ash insoluble in hydrochloric acid - 0,80 ±0,10%; extractable matter in water, ethanol 30%, 50%, 70%, 96% − 33,07±1,21%; 31,54±1,03%; 30,10±0,93%; 28,08±0,90; 18,01±0,87%, respectively; foreign matter (foreign organs which changed color: 2,7%, not defined as drug: 7,1%; foreign elements: 0,9%; mineral matter: 0,9%) and the degree of crushing (for whole plant maximum content 74,3±0,4% with size >7 mm, cut plant 71,8±0,6% with size 3-5 mm)) and the main technological parameters (bulk weight: 1,257 - 1,290 g/сm3; volumetric weight: 0,3773 − 0,3784 g/сm3; specific mass: 2,8219 − 2,8430 g/сm3; free volume of layers: 0,9544 - 0,9557 g/сm3; porosity: 0,8660 − 0,8690 g/сm3; pore space: 0,6581 − 0,6670 g/сm3) of Nepeta cataria L. have been determined. The received results allow to evaluate the quality of raw materials of the Catnip and will be further used in the development of normative documents on this medicinal vegetable raw materials. Technological parameters allow to determine the necessary equipment, develop the optimal technology of manufacture оf phytopreparation based on the raw material of the Catnip.

Keywords: 
Nepeta cataria L.
quality indicators of pharmacopoeia
technological parameters

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References: 
  1. Palij I.N. Fiziologicheskie osobennosti Agasta chefoeniculum
  2. Pursh Nepeta cataria var. Citriodora Veck. v uslovijah juzhnogo berega Kryma: Avtoref. diss. ... kand. biol. nauk. Voronezh. gos. un-t. Jalta. 2015. 181 s.
  3. Adiguzel A., et al. Antimicrobial and antioxidant activity of the essential oil and methanol extract of Nepeta cataria // Polish Journal of Microbiology. 2009. V. 58. № 1. P. 69–76.
  4. Duda S.C., et al. Changes in major bioactive compounds with antioxidant activity of Agasta chefoeniculum, Lavandula angustifolia, Melissa officinalis and Nepeta cataria: Effect of harvest time and plant species // Industrial Crops and Products. 2015. № 77. P. 499–507.
  5. Dutova S.V. Immunostimulirujuschie svojstva nekotoryh rastenij Sibiri // Farmatsija. 2015. № 2. S. 51–53.
  6. Prescott T.A.K., et al. Direct inhibition of calcineurin by caffeoylphenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria // Journal of ethnopharmacology. 2011. V. 137. № 3. P. 1306–1310.
  7. Fan J., et al. Mechanism of modulation through PI3K-AKT pathway about Nepeta cataria L.’s extract in non-small cell lung cancer // Oncotarget. 2017. V. 8. № 19. P. 31395–31405.
  8. French pharmacopoeia 10th edition reviewed. 2000 – Nepeta cataria L. Catnip, leave, fruit. Rezhim dostupa − URL: http://www.phytomania.com/2pharmacopoeia.htm (Data obraschenija 01.07.2017).
  9. The homoeopathic pharmacopoeia of the United States Revision Service 2004. P. 1504. Rezhim dostupa − URL https://docslide.com.br/documents/hpus-complete-book.html (Data obraschenija 26.01.2018).
  10. Gosudarstvennaja farmakopeja Rossijskoj Federatsii XIII. Tom II. 2015. Rezhim dostupa − URL: http://www.femb.ru/feml (Data obraschenija 01.07.2017).
  11. Zhaparkulova K.A. i dr. Opredelenie farmako-tehnologicheskih parametrov i farmakopejnyh pokazatelej kachestva lekarstvennogo rastitel'nogo syr'ja ziziforybunge // Vestnik Almatinskogo tehnologicheskogo universiteta. 2016.№ 1.S. 82–87.
  12. Chueshov V.I., Chernov M.Ju, Hohlova L.M. i dr. Promyshlennaja tehnologija lekarstv. Har'kov: MTK-Kniga; NFAU. 2002. 716 s.
  13. . Karabintseva N.O. Tehnologija proizvodstva ekstraktsionnyh fitopreparatov: ucheb.-metod. posobie. Novosibirsk: Sibmedizdat NGMU. 2010. 130 s.