INFLUENCE OF POTENTILLA ALBA L. ON THE DEVELOPMENT OF OFFSPRING RATS IN THE ANTENATAL AND POSTNATAL PERIODS OF DEVELOPMENT

Рurpose: the study of the influence of Potentilla alba extract dry on embryogenesis of rats. Methods: extract is obtained from the dried roots and rhizomes of the cultivated plant Potentilla alba L. Rats were injected into the stomach from the 1st to the 19th day of pregnancy at doses of 25 (II group) and 125 mg/kg (III group), the maximum of which was 40 times higher than the daily therapeutic dose (3 mg/kg). Controls were intact rats (group I). Assessment of the offspring conducted on the 20th day of pregnancy. Was determined pre - and postimplantation death, conducted an external examination of the fruit, measured their size and body weight, assessed the state of their internal organs by the method of Wilson and the skeletal system by the method of Dawson. In the postnatal period of development took into account the increase in body weight, survival, as well as the rate of formation of sensory-motor reflexes during feeding in the tests: turning on the plane (2nd day), negative geotaxis (7-8-day), turning in free fall (20th day), muscle strength (20th–21st day), open field (30th day). Results: the introduction of Potentilla alba extract female rats from 1 to 19 days of pregnancy in doses of 25 and 125 mg/kg (8 and 40-fold) did not affect the dynamics of body weight of pregnant rats and fetal death. The Potentilla alba extract in the studied doses did not exert damaging effect on the condition of the internal organs of the embryos, but has slowed the rate of ossification of the cartilaginous part of bones bookmark the 20-day fetus-es. The studied extract did not affect the physical development, survival and speed of the rat sensory-motor reflexes, except for the reduction of mus-cle strength and mink reflex in the postnatal period of development. Conclusions: the introduction of Potentilla alba extract into the stomach of pregnant rats in the studied doses has a negative impact on the off-spring of rats in the ante - and postnatal periods of development. The medicines created on the basis of Potentilla alba, during pregnancy should be determined by the doctor and in the case when the expected benefits exceed the possible risks to the fetus.