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DRUG TREATMENT FOR PATIENTS WITH OVARIAN CANCER PART 3. ANTI-ANGIOGENIC DRUGS, FOLATE RECEPTOR INHIBITORS, PARP, WEE1 INHIBITORS AND IMMUNOTHERAPY FOR PLATINUM-RESISTANT RELAPSES; HORMONE THERAPY FOR OVARIAN CANCER

DOI: https://doi.org/10.29296/25877313-2018-09-02
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Issue: 
9
Year: 
2018

S.V. Khokhlova Dr.Sc. (Med.), Chief Research Scientist, Chemotherapy Department, N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia (Moscow) E-mail: svkhokhlova@mail.ru D.N. Kushlinsky Ph.D. (Med.), Oncogynecologist, Department of Innovative Oncology and Gynecology, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology of the Ministry of Health of Russia (Moscow)

Contemporary foreign and domestic publications concerning the issues of pharmacologic treatment of ovarian cancer patients are reviewed. Clinical significance of anti-angiogenic drugs, folate receptor inhibitors, PARP, WEE1 and immunotherapy for platinum-resistant relapses is discussed. This part of the review is devoted to hormone therapy for ovarian cancer. Taking into account the key clinical, morphological and molecular-biological characteristics of ovarian cancer, the published data on the prognosis of drug therapy for these neoplasms are discussed.
Keywords: 
ovarian cancer
drug therapy
anti-angiogenic drugs
folate receptor inhibitors
PARP
WEE1
immunotherapy
platinum-resistant re-lapses
hormone therapy

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